Centrosome instability: when good centrosomes go bad
| Autor: | Gregory C. Rogers, John M. Ryniawec |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Centrosome Organelles Centriole Genetic Diseases Inborn Mitosis Microtubule organizing center Cell Biology Biology Cell biology Spindle apparatus Cellular and Molecular Neuroscience Microtubule Chromosomal Instability Neoplasms Molecular Medicine Animals Humans Interphase Molecular Biology Pericentriolar material |
| Zdroj: | Cellular and molecular life sciences : CMLS. 78(21-22) |
| ISSN: | 1420-9071 |
| Popis: | The centrosome is a tiny cytoplasmic organelle that organizes and constructs massive molecular machines to coordinate diverse cellular processes. Due to its many roles during both interphase and mitosis, maintaining centrosome homeostasis is essential to normal health and development. Centrosome instability, divergence from normal centrosome number and structure, is a common pathognomonic cellular state tightly associated with cancers and other genetic diseases. As novel connections are investigated linking the centrosome to disease, it is critical to understand the breadth of centrosome functions to inspire discovery. In this review, we provide an introduction to normal centrosome function and highlight recent discoveries that link centrosome instability to specific disease states. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink