Zika virus infection associated with autism spectrum disorder: a case report
| Autor: | Rudimar dos Santos Riesgo, Rafael Lopes da Rosa, Markus Berger, Lavinia Schuler-Faccini, Avessandra Costa Cardoso de Oliveira, André Quincozes-Santos, Lucélia Santi, Jorge A. Guimarães, Diogo O. Souza, Emanuela Fernanda Tureta, Patricia Cristina Baleeiro Beltrão-Braga, Walter O. Beys-da-Silva |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pediatrics biology Endocrine and Autonomic Systems business.industry Immunology medicine.disease biology.organism_classification Zika virus DOENÇAS CONGÊNITAS Congenital infections Endocrinology Neurology Neuroimaging Autism spectrum disorder mental disorders Epidemiology EEG Findings medicine business Exome sequencing SNP array |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Introduction: The aim of this case was to investigate the association of the Zika virus infection in utero with the autism spectrum disorder (ASD) as clinical outcome that presented no congenital anomalies. Methods: ASD was diagnosed in the second year of life by different child neurologists and confirmed by DSM-5 and ASQ. After that, an extensive clinical, epidemiological, and genetic evaluations were performed, with main known ASD causes ruled out. Results: An extensive laboratorial search was done, with normal findings. SNP array identified no pathogenic variants. Normal neuroimaging and EEG findings were also obtained. ZIKV (Zika virus) IgG was positive, while IgM was negative. Other congenital infections were negative. The exome sequencing did not reveal any pathogenic variant in genes related to ASD. Conclusion: Accordingly, this report firstly associates ZIKV exposure to ASD. |
| Databáze: | OpenAIRE |
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