Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice
| Autor: | Alexandra Marziou, Julien Astier, Charlène Couturier, Catherine M. Riva, Philippe Obert, Jean-François Landrier, Clothilde Philouze |
|---|---|
| Přispěvatelé: | EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), Avignon Université (AU), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Lucas, Nelly, Roswell Park Cancer Institute [Buffalo], Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Blood Glucose Male medicine.medical_specialty obesity Adipose Tissue White Adipose tissue 030209 endocrinology & metabolism Inflammation lcsh:TX341-641 vitamin D Diet High-Fat Article 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Dietary Sucrose Lipid droplet Internal medicine medicine Vitamin D and neurology steatosis Glucose homeostasis Animals 2. Zero hunger Nutrition and Dietetics Triglyceride business.industry tertiary prevention medicine.disease 3. Good health adipose tissue Fatty Liver Mice Inbred C57BL [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition 030104 developmental biology Endocrinology chemistry inflammation Lipogenesis Dietary Supplements Steatosis medicine.symptom business lcsh:Nutrition. Foods and food supply [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Food Science |
| Zdroj: | Nutrients Nutrients, 2020, 12 (2), pp.342. ⟨10.3390/nu12020342⟩ Nutrients, Vol 12, Iss 2, p 342 (2020) Nutrients, MDPI, 2020, 12 (2), pp.342. ⟨10.3390/nu12020342⟩ Volume 12 Issue 2 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12020342⟩ |
| Popis: | International audience; The beneficial effect of vitamin D (VD) supplementation on body weight gain limitation and inflammation has been highlighted in primary prevention mice models, but the long-term effect of VD supplementation in tertiary prevention has never been reported in obesity models. The curative effect of VD supplementation on obesity and associated disorders was evaluated in high-fat- and high-sucrose (HFS)-fed mice. Morphological, histological, and molecular phenotype were characterized. The increased body mass and adiposity caused by HFS diet as well as fat cell hypertrophy and glucose homeostasis were not improved by VD supplementation. However, VD supplementation led to a decrease of HFS-induced inflammation in inguinal adipose tissue, characterized by a decreased expression of chemokine mRNA levels. Moreover, a protective effect of VD on HFS-induced hepatic steatosis was highlighted by a decrease of lipid droplets and a reduction of triglyceride accumulation in the liver. This result was associated with a significant decrease of gene expression coding for key enzymes involved in hepatic de novo lipogenesis and fatty acid oxidation. Altogether, our results show that VD supplementation could be of interest to blunt the adipose tissue inflammation and hepatic steatosis and could represent an interesting nutritional strategy to fight obesity-associated comorbidities. |
| Databáze: | OpenAIRE |
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