Changes in the Structure of Mouse Kidney in the Acute Period after Infection with Influenza Viruses A/H5N1 and A/H1N1

Autor: A S Mezhevalova, Alexander Shestopalov, V. A. Shkurupy, O. V. Potapova, L. A. Cherdantseva, A. V. Kovner
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Cell
Kidney Glomerulus
Ischemia
Lipopolysaccharide Receptors
Gene Expression
Nitric Oxide Synthase Type II
medicine.disease_cause
General Biochemistry
Genetics and Molecular Biology
Transforming Growth Factor beta1
03 medical and health sciences
Mice
0302 clinical medicine
Influenza A Virus
H1N1 Subtype
Orthomyxoviridae Infections
medicine
Influenza A virus
Animals
Outbred Strains
Animals
Antigens
Viral
Kidney
Interleukin-16
Mice
Inbred BALB C
biology
Influenza A Virus
H5N1 Subtype
Tumor Necrosis Factor-alpha
Macrophages
Endothelial Cells
General Medicine
medicine.disease
Virology
Thrombosis
Influenza A virus subtype H5N1
030104 developmental biology
medicine.anatomical_structure
Host-Pathogen Interactions
Mesangial Cells
biology.protein
Antibody
030217 neurology & neurosurgery
Blood vessel
Zdroj: Bulletin of experimental biology and medicine. 166(3)
ISSN: 1573-8221
Popis: Changes in the kidney structure in outbred and inbred male BALB/c mice were analyzed in the acute period after infection with influenza viruses A/H5N1 (10 MLD50; 10 days) and A/H1N1 (1 MLD50; 30 days). Antibodies to influenza viruses of both strains were most often expressed by endothelial cells of the glomeruli and arterioles and were rarely expressed by mesangiocytes and tubule epithelial cells. In the kidney, destructive processes induced by viruses and by ischemia due to massive blood vessel thrombosis. Mesangiocytes expressed factors, indicating that they could be qualified as M1 and M2 macrophages. Kidney destruction was more significant after infection of mice with the A/H5N1 virus, but in both experiments cell infiltrates were actually absent, probably due to blood vessel thrombosis and limited possibility of migration of mononuclear phagocytes and lymphocytes to the kidney.
Databáze: OpenAIRE
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