Antiproliferative Effect of Indole Phytoalexins
| Autor: | Jan Mojzis, František Zigo, Martina Chripkova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Indoles Stereochemistry Pharmaceutical Science Review indole phytoalexins Biology Analytical Chemistry lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine lcsh:Organic chemistry Phytoalexins antiproliferative Drug Discovery Tumor Cells Cultured Humans cancer Physical and Theoretical Chemistry Cell Proliferation Indole test Molecular Structure Organic Chemistry Antimicrobial Key features 030104 developmental biology Biochemistry crucifers Chemistry (miscellaneous) 030220 oncology & carcinogenesis Brassicaceae Molecular mechanism Molecular Medicine brassinin Antiproliferative effect Sesquiterpenes |
| Zdroj: | Molecules, Vol 21, Iss 12, p 1626 (2016) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Indole phytoalexins from crucifers have been shown to exhibit significant anti-cancer, chemopreventive, and antiproliferative activity. Phytoalexins are natural low molecular antimicrobial compounds that are synthesized and accumulated in plants after their exposure to pathogenic microorganisms. Most interestingly, crucifers appear to be the only plant family producing sulfur-containing indole phytoalexins. The mechanisms underlying its anti-cancer properties are unknown. Isolation from cruciferous plants does not provide sufficient quantities of indole phytoalexins and, for biological screening, they are usually obtainable through synthesis. Understanding the molecular mechanism of the action of these substances and their structure-activity relationships is quite important in the development of new analogs with a more favorable profile of biological activities. In this review, we present the key features of indole phytoalexins, mainly their antiproliferative ativities. |
| Databáze: | OpenAIRE |
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