Characterization of the Peritumoral Atrophic Band and Nonneoplastic Renal Parenchyma in Radical Nephrectomy Specimens
| Autor: | Bhavna Bhasin, Kenneth A. Iczkowski, Carl Dernell, Alexander J. Gallan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty medicine.medical_treatment Kidney Nephrectomy Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Parenchyma medicine Humans Diabetic Nephropathies 030212 general & internal medicine Aged Aged 80 and over business.industry Glomerulosclerosis General Medicine Middle Aged medicine.disease Kidney Neoplasms medicine.anatomical_structure Renal pathology 030220 oncology & carcinogenesis Female business Kidney disease |
| Zdroj: | American Journal of Clinical Pathology. 156:913-919 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | Objectives Pathologic evaluation of nonneoplastic renal parenchyma in nephrectomy specimens is important for identifying chronic kidney disease and diabetic nephropathy, but increasing utilization of partial nephrectomies has led to less-sampled nonneoplastic parenchyma. The sampled tissue is often composed predominantly of the peritumoral atrophic band (PAB) directly adjacent to the tumor. We sought to determine the characteristics of the PAB and whether it could be used to reliably assess kidney pathology, including diabetic nephropathy. Methods We investigated 59 radical nephrectomies to determine the PAB characteristics, whether the PAB is representative of distant nonneoplastic parenchyma, and if diabetic nephropathy could be reliably detected in the PAB. Results Mesangial sclerosis was detected within the PAB in 100% of cases with mesangial sclerosis in the distant parenchyma. Eighty percent had a history of diabetes. The PAB exhibited increased glomerular sclerosis (51% vs 13%, P Conclusions Diabetic nephropathy can be reliably detected in the PAB, which is important in partial nephrectomies or renal mass biopsies without ample distant renal parenchyma. The degree of glomerular and tubulointerstitial scarring within the PAB does not reflect the overall degree of chronic kidney disease. |
| Databáze: | OpenAIRE |
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