Dibutylchloromethyltin chloride, a potent inhibitor of electron transport in plant mitochondria

Autor:	Anthony L. Moore, Beechey Rb, Linnett Pe
Rok vydání:	1980
Předmět:	Membrane potential Alternative oxidase Physiology food and beverages Cell Biology Plants Biology Mitochondrion Electron transport chain Mitochondria Hypocotyl Electron Transport Oxygen Consumption Biochemistry Etiolation Respiration Organotin Compounds Bioorganic chemistry Trialkyltin Compounds
Zdroj:	Journal of Bioenergetics and Biomembranes. 12:309-323
ISSN:	1573-6881 0145-479X
DOI:	10.1007/bf00744691
Popis:	Dibutylchloromethyl tin chloride (DBCT) inhibits coupled and uncoupled respiration of mitochondria from potato tubers, cauliflower florets and etiolated mung bean hypocotyls with succinate and L-malate but not with external NADH or TMPD/ascorbate as substrates. Using potato and cauliflower mitochondria. DBCT at 200 pmole/mg of protein gives complete inhibition only in KCl-based media and at pH 6.8. DBCT has no effect on the internal pH of mung bean mitochondria, but does cause a decrease in the membrane potential. Electron transport through the alternative oxidase is not inhibited, neither is the ATP-synthase system. DBCT appears to interact with the functionally-distinct pool of ubiquinone associated with the oxidation of succinate and L-malate.
Databáze:	OpenAIRE
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