Energy Expenditure Improved Risk Factors Associated with Renal Function Loss in NAFLD and MetS Patients
| Autor: | Maria Angeles Zulet, Cristina Gómez, Itziar Abete, J. Alfredo Martínez, Miguel Casares, María Barbería-Latasa, Escarlata Angullo-Martinez, Josep A. Tur, Manuela Abbate, Sofía Montemayor, Antoni Sureda, Catalina M. Mascaró, Silvia Tejada |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Mediterranean diet Urinary system Renal function 030209 endocrinology & metabolism lcsh:TX341-641 albumin-to-creatinine ratio Diet Mediterranean Kidney Kidney Function Tests Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Insulin resistance Risk Factors Internal medicine medicine Albuminuria Humans 030212 general & internal medicine Exercise Life Style Metabolic Syndrome Nutrition and Dietetics business.industry Fatty liver non-alcoholic fatty liver disease glomerular hyperfiltration Middle Aged medicine.disease Liver Creatinine Female caloric restriction Insulin Resistance medicine.symptom Metabolic syndrome Energy Metabolism business lcsh:Nutrition. Foods and food supply Glomerular hyperfiltration increased energy expenditure Glomerular Filtration Rate Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 629, p 629 (2021) Nutrients Volume 13 Issue 2 |
| ISSN: | 2072-6643 |
| Popis: | To assess the efficacy of three lifestyle interventions on the reduction of liver fat content and metabolic syndrome (MetS), and whether such reductions would influence renal outcomes, we conducted a randomized controlled trial on 128 participants with MetS and non-alcoholic fatty liver disease (NAFLD), as well as available data on estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatine ratio (UACR). Patients were randomized in 1:1:1 ratio to either Conventional Diet, Mediterranean diet (MD)–high meal frequency, and MD–physical activity groups. Each intervention aimed at reducing caloric intake by 25%–30% of baseline intake and increase energy expenditure by 400 kcal/70 kg. Patients attended regular visits and were followed-up for 6 months. Increased albuminuria was present in 13.3% of patients, while 32.8% showed hyperfiltration. UACR reduction was associated with higher levels of UACR at baseline but not with changes in liver fat. eGFR decreased in patients presenting hyperfiltration at baseline and was associated with reduction in liver fat and insulin resistance, as well as with increase in energy expenditure (R2 = 0.248, p = 0.006). No significant differences were observed between the three treatment groups. In patients with NAFLD and MetS, energy expenditure significantly reduced hepatic fat accumulation and insulin resistance, which reduced glomerular hyperfiltration. Increased albuminuria was reduced, but it was not associated with reduced liver fat. |
| Databáze: | OpenAIRE |
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