Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts

Autor:	Stefanie Korntner, Andrea De Pieri, Dimitrios I. Zeugolis, Héctor Capella-Monsonís, Rita Peixoto
Jazyk:	angličtina
Předmět:	0301 basic medicine Pathology medicine.medical_specialty Swine Angiogenesis Human adipose-derived stem cell delivery 0206 medical engineering Medicine (miscellaneous) Wound healing Biocompatible Materials 02 engineering and technology Matrix (biology) Biochemistry Genetics and Molecular Biology (miscellaneous) Regenerative medicine Extracellular matrix lcsh:Biochemistry 03 medical and health sciences medicine Animals lcsh:QD415-436 Basement membrane lcsh:R5-920 Collagen scaffolds Tissue Scaffolds Chemistry Research Stem Cells Biomaterial Cell Biology Decellularised grafts 020601 biomedical engineering Extracellular Matrix 3. Good health 030104 developmental biology medicine.anatomical_structure Adipose Tissue Heterografts Molecular Medicine Collagen Stem cell lcsh:Medicine (General)
Zdroj:	Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-15 (2020) Stem Cell Research & Therapy
ISSN:	1757-6512
DOI:	10.1186/s13287-020-02021-x
Popis:	Background Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. scaffolds and tissue grafts), due to their compositional biofunctionality and cytocompatibility, are under investigation as potential stem cell carriers. Methods The present study assessed the potential of three commercially available extracellular matrix-based biomaterials [a collagen/glycosaminoglycan scaffold (Integra™ Matrix Wound Dressing), a decellularised porcine peritoneum (XenoMEM™) and a porcine urinary bladder (MatriStem™)] as human adipose-derived stem cell delivery vehicles. Results Both tissue grafts induced significantly (p p p p < 0.01, was observed for the cell loaded at the basement membrane XenoMEM™ group). All cell-loaded biomaterial groups retained more cells at the implantation side than the direct injection group, even though they were loaded with half of the cells than the cell injection group. Conclusions This study further advocates the use of extracellular matrix-based biomaterials (in particular porcine peritoneum) as human adipose-derived stem cell delivery vehicles. Graphical abstract Comparative analysis of a collagen scaffold (Integra™ Matrix Wound Dressing) and two tissue grafts [decellularised porcine peritoneum (XenoMEM™) and porcine urinary bladder (MatriStem™)] as human adipose-derived stem cells carriers
Databáze:	OpenAIRE
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