Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition

Autor:	Jun Hu, Wei-Cai Xu, Zhi-Jie Rong, Runming Zeng, Jing Lin, Wanting Zeng, Xiaohui Lu, Zewa Liu
Rok vydání:	2019
Předmět:	0301 basic medicine Male medicine.drug_class Neutrophils Immunology Anti-Inflammatory Agents omega-Chloroacetophenone Peritonitis Inflammation Hyperuricemia Pharmacology Toxicology Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine NLR Family Pyrin Domain-Containing 3 Protein medicine Immunology and Allergy Animals Creatinine Mice Inbred ICR business.industry Arthritis Gouty Therapeutic effect General Medicine Neutrophil cytosolic factor 1 medicine.disease Triterpenes Uric Acid 030104 developmental biology chemistry Neutrophil Infiltration 030220 oncology & carcinogenesis Cytokines medicine.symptom business Infiltration (medical)
Zdroj:	Immunopharmacology and immunotoxicology. 41(2)
ISSN:	1532-2513
Popis:	Objectives: Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints, which is associated with the rise of serum urate content. This study aims to investigate the therapeutic effect of Madecassoside on gouty arthritis and hyperuricemia. Methods: DBA/1 mice were intradermally injected with MSU to stimulate joint inflammation or intraperitoneally injected with MSU to trigger peritonitis. Moreover, ICR mice were exposed to potassium oxonate to stimulate hyperuricemia. Results: Madecassoside repressed MSU-triggered pad swelling, joint 99mTc uptake, and joint inflammation in DBA/1 mice with gouty arthritis. Neutrophil infiltration and IL-1β & IL-6 & MCP-1 secretion was also alleviated in lavage fluids from DBA/1 mice with peritonitis due to Madecassoside treatment. Furthermore, Madecassoside decreased MSU-induced neutrophil cytosolic factor 1, caspase-1 and NLRP3 expression in mice with peritoneal inflammation. In hyperuricemic mice, Madecassoside improved renal dysfunction. Serum uric acid, BUN, and creatinine were down-regulated by Madecassoside. Conclusion: These findings indicate that Madecassoside has potential to ameliorate inflammation in both acute gouty arthritis model and peritonitis model, probably via regulating IL-1β and NLRP3 expression. Practical point: Madecassoside also exhibited a urate-lowering effect and a renal protective effect in hyperuricemic mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a42e53d5e18b7aade1e7281c8c7271 https://pubmed.ncbi.nlm.nih.gov/31084401 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.