Laboratory Findings of COVID-19 Infection are Conflicting in Different Age Groups and Pregnant Women: A Literature Review

Autor: Hamed Akbari, Reza Tabrizi, Morteza Jafarinia, Sina Vakili, Sheida Jamalnia, Amir Savardashtaki, Mohammad Hadi Nematollahi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
BUN
blood urea nitrogen
AST
aspartate aminotransferase
Disease
Procalcitonin
0302 clinical medicine
COVID-19 Testing
Pregnancy
Pandemic
Diagnosis
RT-PCR
real-time reverse transcription-polymerase chain reaction
Leukocytosis
Pregnancy Complications
Infectious
Child
PTT
partial thromboplastin time
COVID-19
coronavirus disease 2019
education.field_of_study
LDH
lactate dehydrogenase
General Medicine
Middle Aged
030220 oncology & carcinogenesis
Child
Preschool
Viral pneumonia
CRP
C-reactive protein
Female
medicine.symptom
WBC
white blood cell
Adult
Laboratory findings
medicine.medical_specialty
Adolescent
Coronavirus disease 2019 (COVID-19)
Population
Article
03 medical and health sciences
Young Adult
Age
Age groups
ALT
alanine aminotransferase
PT
prothrombin time
Internal medicine
medicine
Humans
education
ARDS
acute respiratory distress syndrome
Aged
ESR
erythrocyte sedimentation rate
SARS-CoV-2
business.industry
Infant
Newborn
COVID-19
Infant
Outbreak
medicine.disease
030104 developmental biology
business
SARS-CoV-2
severe acute respiratory syndrome coronavirus-2
CK
creatine kinase
Biomarkers
Zdroj: Archives of Medical Research
ISSN: 0188-4409
DOI: 10.1016/j.arcmed.2020.06.007
Popis: Coronavirus disease 2019 (COVID-19), a new type and rapidly spread viral pneumonia, is now producing an outbreak of pandemic proportions. The clinical features and laboratory results of different age groups are different due to the general susceptibility of the disease. The laboratory findings of COVID-19 in pregnant women are also conflicting. Para-clinical investigations including laboratory tests and radiologic findings play an important role in early diagnosis and treatment monitoring of COVID-19. The majority of previous reports on the COVID-19 laboratory results were based on data from the general population and limited information is available based on age difference and pregnancy status. This review aimed to describe the COVID-19 laboratory findings in neonates, children, adults, elderly and pregnant women altogether for the first time. The most attracting and reliable markers of COVID-19 in patients were: normal C-reactive protein (CRP) and very different and conflicting laboratory results regardless of clinical symptoms in neonates, normal or temporary elevated CRP, conflicting WBC count results and procalcitonin elevation in children, lymphopenia and elevated lactate dehydrogenase (LDH) in adult patients, lymphopenia and elevated CRP and LDH in the elderly people and high CRP, leukocytosis and elevated neutrophil ratio in pregnant women.
Highlights The most attracting and reliable markers of COVID-19 in patients were as follows:•Normal C-reactive protein (CRP) and very different and conflicting laboratory results regardless of clinical symptoms in neonates•Normal or temporary elevated CRP, conflicting WBC count results and procalcitonin elevation in children•Lymphopenia and elevated lactate dehydrogenase (LDH) in adult patients•Lymphopenia and elevated CRP and LDH in the elderly people and high CRP•Leukocytosis and elevated neutrophil ratio in pregnant women.
Databáze: OpenAIRE
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