KF/Clinoptilolite Nanoparticles as a Heterogeneous Catalyst for Green Synthesis of pyrido[2,1-a]isoquinolines using Four-Component Reaction of Alkyl Bromides
| Autor: | Fatemeh Sheikholeslami-Farahani, Maryam Ghazvini, Mohammad T.B. Jamnani, Naghmeh Faal Hamedani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Potassium Compounds
Surface Properties Nanoparticle 010402 general chemistry Heterogeneous catalysis 01 natural sciences Catalysis Fluorides chemistry.chemical_compound Drug Discovery Particle Size Isoquinoline Alkyl chemistry.chemical_classification Clinoptilolite Molecular Structure 010405 organic chemistry Organic Chemistry Imidazoles General Medicine Isoquinolines Hydrocarbons Brominated 0104 chemical sciences Computer Science Applications Solvent chemistry Yield (chemistry) Zeolites Nanoparticles Dispersion (chemistry) Nuclear chemistry |
| Zdroj: | Combinatorial Chemistry & High Throughput Screening. 22:728-739 |
| ISSN: | 1386-2073 |
| DOI: | 10.2174/1386207323666191213143417 |
| Popis: | Objective:KF/Clinoptilolite nanoparticles are employed as as a heterogeneous catalyst for the preparation of pyrido[2,1-a]isoquinoline derivatives through a four-component reaction of isoquinoline, two different alkyl bromides and an electron deficient internal alkynes at ambient temperature in water as green solvent.Methods:In this research, (2,2-Diphenyl-1-picrylhydrazyl) radical trapping and reducing potential of ferric ion experiments was used for determining antioxidant activity of some newly synthesized compounds such as 5a, 5c, 5f and 5g and comparing results with synthetic antioxidants (TBHQ and BHT).Results:Compounds 5a, 5c, 5f and 5g display trace DPPH radical trapping and excellent reducing power of ferric ion. Furthermore, the power of some prepared compounds against Gram-positive and Gram-negative bacteria was proved by employing the disk dispersion experiment.Conclusion:The obtained results of disk diffusion test showed that compounds 5a, 5d and 5e prevented the bacterial growth. The reported procedure shows the advantages of clean reaction, high yield and simple purification. |
| Databáze: | OpenAIRE |
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