SIGNIFICANCE OF ISCHEMIA-MODIFIED ALBUMIN AS A SIMPLE MEASURE OF OXIDATIVE STRESS AND ITS DISCRIMINATORY ABILITY IN DIABETIC RETINOPATHY
| Autor: | Poonam Agrawal, Ram Chander Siwach, Varikasuvu Seshadri Reddy, Sumita Sethi, Navdeep Gupta |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Urology Serum albumin Serum Albumin Human 030209 endocrinology & metabolism medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Diabetes Mellitus Humans Medicine In patient Serum Albumin Diabetic Retinopathy biology business.industry Ischemia-modified albumin General Medicine Diabetic retinopathy medicine.disease Surgery Oxidative Stress Ophthalmology Strictly standardized mean difference Meta-analysis 030221 ophthalmology & optometry biology.protein business Biomarkers Oxidative stress |
| Zdroj: | Retina. 36:1049-1057 |
| ISSN: | 0275-004X |
| DOI: | 10.1097/iae.0000000000001042 |
| Popis: | PURPOSE Oxidative stress (OXS) plays critical role in the development of diabetic retinopathy (DRP). Increased concentrations of serum ischemia-modified albumin (IMA) have been demonstrated as a novel and inexpensive measure of oxidative stress. Although few pilot studies have reported increased IMA in DRP, the available literature is limited to comprehensively describe the potential significance of IMA in predicting DRP. METHODS The authors performed a meta-analysis to investigate IMA in DRP compared with control and diabetes mellitus subjects. The authors also performed a meta-analysis of area under curve for IMA. PubMed (Medline), Embase, Scopus, Web of Science, Science Direct, Springer Link, and Google Scholar databases were searched for relevant studies in serum IMA in DRP. The authors obtained five observational studies. Meta-analysis was performed using Review Manager 5.3 and MEDCALC 15.8 software to present the pooled-overall effect size as standardized mean difference and overall area under curve value of IMA. RESULTS Random-effects meta-analysis indicated a significant increase in serum IMA in patients with DRP compared with control (standardized mean difference = 2.48, P < 0.0001) and diabetes mellitus groups (standardized mean difference = 1.43, P < 0.0001). Our results also show that IMA can significantly predict the development of DRP (area under curve = 0.86, P < 0.001). CONCLUSION Serum IMA may be useful as a simple marker in monitoring of oxidative stress status in DRP and showed significant discriminatory ability in DRP. Future comparative studies in large are needed to further investigate IMA in different types of DRP; proliferative and nonproliferative. |
| Databáze: | OpenAIRE |
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