Common players in mitochondria biogenesis and neuronal protection against stress-induced apoptosis
| Autor: | Emmanouela Kallergi, Kostas Tokatlidis, Katerina Karagouni-Dalakoura, Ester Kalef-Ezra |
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| Rok vydání: | 2013 |
| Předmět: |
Neurons
biology Mitochondrial intermembrane space Apoptosis Neurodegenerative Diseases General Medicine medicine.disease_cause Biochemistry Cell biology Mitochondria Mitochondrial Proteins Cellular and Molecular Neuroscience Mitochondrial membrane transport protein Stress Physiological Translocase of the inner membrane Protein targeting biology.protein medicine Apoptosis-inducing factor Animals Humans Mitochondrial fission Organelle biogenesis Intermembrane space |
| Zdroj: | Neurochemical research. 39(3) |
| ISSN: | 1573-6903 |
| Popis: | Mitochondria biogenesis is a fundamental process for the organization and normal function of all cells. Since the majority of mitochondrial proteins are synthesized in the cytosol, protein import is the major mechanism for mitochondria biogenesis. We describe the different pathways that ensure correct targeting and intra mitochondrial sorting of mitochondrial proteins. The import process of several proteins of the mitochondrial intermembrane space relies on the Mitochondrial Import and Assembly 40 and Essential for respiration and vegetative growth 1 (Erv1) proteins that together constitute the oxidative folding machinery of the mitochondrial intermembrane space. Recent work has implicated the FAD-oxidase protein Erv1 (ad its human homolog Augmenter of Liver Regeneration) as an anti-apoptotic factor in mammalian cells (including neuronal cells) that undergo Reactive Oxygen Species-triggered apoptosis. The different roles of this protein as a key factor in mitochondria biogenesis, iron-sulfur cluster biogenesis and in neuronal protection against apoptosis are discussed. |
| Databáze: | OpenAIRE |
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