A pilot study of topical imiquimod therapy for the treatment of recurrent extramammary Paget's disease
Autor: | Eric L. Eisenhauer, Kay J. Park, Floor J. Backes, Dennis S. Chi, Ginger J. Gardner, Destin Black, Mario M. Leitao, Nadeem R. Abu-Rustum, Robert A. Soslow, Renee A. Cowan, Lien N. Hoang |
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Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
Administration Topical Antineoplastic Agents Pilot Projects Imiquimod Disease Extramammary Paget's disease Article Vulva 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Adjuvants Immunologic medicine Humans Prospective cohort study Aged Invasive carcinoma business.industry Obstetrics and Gynecology Middle Aged Vulvar cancer medicine.disease Dermatology Surgery Paget Disease Extramammary medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Aminoquinolines Female Neoplasm Recurrence Local Topical imiquimod business medicine.drug |
Zdroj: | Gynecologic Oncology. 142:139-143 |
ISSN: | 0090-8258 |
Popis: | Objective The objective of this prospective pilot study was to assess the clinical and histologic effects of topical imiquimod therapy on recurrent extramammary Paget's disease of the vulva. Methods Patients with biopsy-proven recurrent extramammary Paget's disease presenting to the gynecology outpatient services at two participating institutions were recruited for conservative treatment with 5% imiquimod cream from 2007 to 2011. The topical cream was to be applied 3 times per week for 12weeks. Punch biopsy and photography were performed at baseline and at the 12-week time point. Results Eight patients from two institutions were enrolled. Complete clinical and histologic response was achieved in 6 (75%) patients by the 12-week follow-up appointment. Of the two remaining patients, one had a complete clinical response but no significant histologic response; the other patient was removed from the study protocol secondary to intolerable local irritation. Two patients continue to have no evidence of disease after a median follow-up of 35months. Five are alive with disease. No patients progressed to invasive cancer while receiving therapy. Conclusion Topical 5% imiquimod cream is a safe and feasible option for women suffering from recurrent extramammary Paget's disease of the vulva, and should be considered as a viable alternative to surgical management. Given the rare nature of this disease, additional multi-institutional prospective studies should be conducted to explore the efficacy of this treatment regime. |
Databáze: | OpenAIRE |
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