In vivo Influence of Nicotine on Human Basal and NSAID-induced Gut Barrier Function
| Autor: | Paul Rutgeerts, Peter Suenaert, Benny Geypens, E. Den Hond, Anja Luypaerts, Fred Monsuur, Veerle Bulteel, Yvo Ghoos |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Drug Nicotine Sucrose medicine.medical_specialty media_common.quotation_subject Indomethacin Carbohydrates 030226 pharmacology & pharmacy Inflammatory bowel disease Permeability 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine In vivo Internal medicine Intestine Small medicine Humans Nicotinic Agonists 030212 general & internal medicine media_common Intestinal permeability Gastric emptying business.industry Anti-Inflammatory Agents Non-Steroidal Gastroenterology Drug Synergism Middle Aged medicine.disease Chromium Radioisotopes Lactulose digestive system diseases Endocrinology Nicotinic agonist Female business Biomarkers medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 38:399-408 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.1080/00365520310000834 |
| Popis: | Smoking reduces the non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal permeability increase in healthy people. It also affects inflammatory bowel disease that is associated with a disturbed gut barrier function. To assess the role of nicotine on barrier function, its influence on basal and NSAID-induced intestinal permeability was studied in healthy volunteers.Thirty-one healthy non-smoker subjects performed permeability tests with 51Cr-EDTA and sugar markers (sucrose, lactulose, mannitol, sucralose) before and during 2 weeks of nicotine patch application, and with and without indomethacin intake, respectively. Since smoking has been described as affecting motility, transit measurements were also done with the sodium[13C]-octanoate and lactose-[13C]-ureide breath tests before and during nicotine exposure. Correlations between permeability markers were checked and the influence of gastrointestinal transit was assessed.Nicotine did not affect barrier function in vivo, nor gastric emptying, small-bowel transit time or orocaecal transit. 51Cr-EDTA and lactulose correlated in basal 0-6 h permeability testing (r = 0.529, P0.0001), as did 6-24 h excretion of 51Cr-EDTA and sucralose (r = 0.474, P0.001); 97% and 90% of the subjects had a permeability increase after indomethacin intake for 0-6 h and 6-24 h excretion of Cr-EDTA, respectively. This population proportion is 63% for lactulose/mannitol and 83% for sucralose.Short-term exposure to nicotine does not alter normal basal or NSAID-induced gut barrier function or transit. 51Cr-EDTA and the respective sugar markers correlate well in in vivo permeability testing in healthy humans. The radioactive test detects more NSAID-induced permeability increase than does the lactulose/mannitol ratio permeability test. |
| Databáze: | OpenAIRE |
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