The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein
| Autor: | Qi Chen, Jiin Tsuey Cheng, Richard Baer, B. Ozanne, W. Crist, L.H. Tasi, George R. Buchanan, AJ Carroll, Nancy R. Schneider, M. Siciliano |
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| Rok vydání: | 1990 |
| Předmět: |
Protein Conformation
T-Cell Acute Lymphocytic Leukemia Protein 1 T cell Molecular Sequence Data T-cell leukemia Chromosomal translocation Biology Polymerase Chain Reaction Translocation Genetic General Biochemistry Genetics and Molecular Biology Gene product TAL effector Sequence Homology Nucleic Acid Chromosome 19 medicine Humans Leukemia-Lymphoma Adult T-Cell Amino Acid Sequence RNA Neoplasm Molecular Biology Chromosomes Human Pair 14 Genetics Base Sequence General Immunology and Microbiology General Neuroscience Chromosome Mapping Nucleic Acid Hybridization DNA Neoplasm Molecular biology Neoplasm Proteins DNA-Binding Proteins medicine.anatomical_structure Genes Chromosomes Human Pair 1 Oligonucleotide Probes Research Article TAL1 |
| Zdroj: | The EMBO Journal. 9:415-424 |
| ISSN: | 0261-4189 |
| DOI: | 10.1002/j.1460-2075.1990.tb08126.x |
| Popis: | We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes. |
| Databáze: | OpenAIRE |
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