Oral Supplementation with Benzylamine Delays the Onset of Diabetes in Obese and Diabetic db-/- Mice
| Autor: | Christian Carpéné, Éva Szökő, Estelle Wanecq, Zsuzsa Iffiú-Soltész, Laszlo Tothfalusi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Benzylamines medicine.medical_treatment Phytochemicals Mice Obese Type 2 diabetes White adipose tissue chemistry.chemical_compound Eating Mice 0302 clinical medicine Adipocyte Medicine Glucose homeostasis Insulin TX341-641 Mice Knockout 0303 health sciences Nutrition and Dietetics Receptors Leptin Amine Oxidase (Copper-Containing) medicine.symptom Glycosuria medicine.medical_specialty insulin-resistant diabetes adipocytes hydrogen peroxide Article Diabetes Mellitus Experimental Diabetes Complications dietary amines 03 medical and health sciences Internal medicine Diabetes mellitus antihyperglycemic phytochemicals Animals Humans Hypoglycemic Agents Obesity 030304 developmental biology Nutrition. Foods and food supply business.industry Glucose transporter glucose transport vascular adhesion protein medicine.disease semicarbazide-sensitive amine oxidase copper containing amine oxidase glycemia Endocrinology Glucose chemistry Diabetes Mellitus Type 2 Hyperglycemia Dietary Supplements business 030217 neurology & neurosurgery Food Science |
| Zdroj: | Nutrients Volume 13 Issue 8 Nutrients, Vol 13, Iss 2622, p 2622 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13082622 |
| Popis: | Substrates of semicarbazide-sensitive amine oxidase (SSAO) exert insulin-like actions in adipocytes. One of them, benzylamine (Bza) exhibits antihyperglycemic properties in several rodent models of diabetes. To further study the antidiabetic potential of this naturally occurring amine, a model of severe type 2 diabetes, the obese db-/- mouse, was subjected to oral Bza administration. To this end, db-/- mice and their lean littermates were treated at 4 weeks of age by adding 0.5% Bza in drinking water for seven weeks. Body mass, fat content, blood glucose and urinary glucose output were followed while adipocyte insulin responsiveness and gene expression were checked at the end of supplementation, together with aorta nitrites. Bza supplementation delayed the appearance of hyperglycemia, abolished polydypsia and glycosuria in obese/diabetic mice without any detectable effect in lean control, except for a reduction in food intake observed in both genotypes. The improvement of glucose homeostasis was observed in db-/- mice at the expense of increased fat deposition, especially in the subcutaneous white adipose tissue (SCWAT), without sign of worsened inflammation or insulin responsiveness and with lowered circulating triglycerides and uric acid, while NO bioavailability was increased in aorta. The higher capacity of SSAO in oxidizing Bza in SCWAT, found in the obese mice, was unaltered by Bza supplementation and likely involved in the activation of glucose utilization by adipocytes. We propose that Bza oxidation in tissues, which produces hydrogen peroxide mainly in SCWAT, facilitates insulin-independent glucose utilization. Bza could be considered as a potential agent for dietary supplementation aiming at preventing diabetic complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|