Plasticisation of amylodextrin by moisture. Consequences for compaction behaviour and tablet properties
| Autor: | Rob Steendam, Coenraad F. Lerk, Henderik W. Frijlink |
|---|---|
| Přispěvatelé: | Pharmaceutical Technology and Biopharmacy, Biopharmaceuticals, Discovery, Design and Delivery (BDDD) |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Materials science
Chemistry Pharmaceutical Compaction Pharmaceutical Science Mineralogy powder Amylodextrin Plasticisation Differential scanning calorimetry Plasticizers Tablet strength moisture Dextrins Ultimate tensile strength Composite material Porosity Water content Elastic modulus drug release tablet model Calorimetry Differential Scanning Moisture starch article Water temperature Humidity tablet porosity Elastic relaxation priority journal Thermodynamics elasticity differential scanning calorimetry Glass transition tablet compression Tablets |
| Zdroj: | European Journal of Pharmaceutical Sciences, 14(3), 245-254. ELSEVIER SCIENCE BV |
| ISSN: | 1879-0720 0928-0987 |
| DOI: | 10.1016/S0928-0987(01)00171-3 |
| Popis: | Purpose: Amylodextrin, a starch-based controlled release excipient, spontaneously absorbs moisture during storage. The aim of this study was to investigate plasticisation of amylodextrin by moisture and its effect on compaction and tablet characteristics. Methods: The glass transition temperature (T-g) of amylodextrin powders with moisture fractions (T-g) 0.070 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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