Inhibition of Glutamate Transporters Results in a 'Suppression-Burst' Pattern and Partial Seizures in the Newborn Rat

Autor: Nathalie Villeneuve, Yehezkel Ben-Ari, Mathieu Milh, Laurent Aniksztejn, Hélène Becq
Přispěvatelé: Epilepsie et ischémie cérébrale, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurophysiologie Clinique, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Tyzio, Roman
Rok vydání: 2007
Předmět:
Male
Amino Acid Transport System X-AG
MESH: Videotape Recording
Kainate receptor
MESH: Aspartic Acid
MESH: Animals
Newborn
Functional Laterality
Epilepsy
chemistry.chemical_compound
0302 clinical medicine
MESH: Animals
Neurotransmitter
Cerebral Cortex
0303 health sciences
Kainic Acid
Pilocarpine
Glutamate receptor
Electroencephalography
Receptors
Glutamate
Neurology
MESH: Amino Acid Transport System X-AG
MESH: Injections
Intraventricular
Ionotropic effect
medicine.drug
MESH: Rats
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
MESH: Receptors
Glutamate
03 medical and health sciences
MESH: Electroencephalography
medicine
Animals
MESH: Functional Laterality
Rats
Wistar
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
Injections
Intraventricular
030304 developmental biology
Aspartic Acid
Videotape Recording
MESH: Rats
Wistar
MESH: Kainic Acid
medicine.disease
MESH: Male
MESH: Pilocarpine
MESH: Cerebral Cortex
Rats
MESH: Epilepsies
Partial
Disease Models
Animal
Electrophysiology
Animals
Newborn
chemistry
Epilepsies
Partial
Neurology (clinical)
MESH: Disease Models
Animal
Hypoactivity
Neuroscience
030217 neurology & neurosurgery
Zdroj: Epilepsia
Epilepsia, Wiley, 2007, 48 (1), pp.169-74. ⟨10.1111/j.1528-1167.2006.00839.x⟩
ISSN: 1528-1167
0013-9580
DOI: 10.1111/j.1528-1167.2006.00839.x
Popis: International audience; PURPOSE: To determine the electrophysiological pattern and propose a clinical relevance of a deficient glutamate transport in the developing brain. METHODS: (a) Surface EEG-video monitoring in freely moving pups; (b) intracortical multiple unit activity (MUA) and local field potential recordings in 5- to 7-day-old rats after pharmacological inhibition of the glutamate transporters by DL-TBOA. RESULTS: Glutamate transporters inhibition alters the background cortical electrical activity inducing a dominant and persistent pattern of bilateral recurrent paroxysmal bursts alternating with periods of hypoactivity and also partial seizures. Intracortical local field recordings show that paroxysmal bursts are associated with multiunits and gamma oscillations separated by periods of silence. This cortical activity involves the activation of ionotropic glutamate receptors and was not observed after kainate and pilocarpine administration. CONCLUSIONS: We show that a dysfunction of glutamate transporters in immature rats leads to a singular cortical activity that is reminiscent of a "suppression-burst" pattern. We propose that an early deficiency of glutamate transport may underlie some early onset epilepsies.
Databáze: OpenAIRE
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