Production of cardiac lesions with tyramine in intact rats

Autor: Mario Condorelli, S. Latte, Massimo Chiariello, Arturo Genovese, W. De Alfieri
Přispěvatelé: Genovese, Arturo, Chiariello, M, De Alfieri, W, Latte, S, Condorelli, M.
Rok vydání: 1983
Předmět:
Zdroj: Basic Research in Cardiology. 78:289-297
ISSN: 1435-1803
0300-8428
DOI: 10.1007/bf01907438
Popis: The authors performed an experimental study on myocardial injury induced by tyramine. For this purpose Sprague-Dawley male rats received multiple dose levels of tyramine hydrochloride. The drug exerts its sympathomimetic effects chiefly by the release of catecholamines stored in nerve endings. Myocardial lesions were documented on the basis of serum creatinkinase isoenzyme (MB-CK) changes and creatinkinase activity (CK) depletion in homogenate of cardiac tissue in animals sacrificed at different time intervals from tyramine injection. Accordingly, MB-CK values expressed as IU/l×103 (mean±standard error of the mean, [SEM]) assessed at the 2nd and 4th hours from 50, 100, or 150 mg i.p. tyramine/100 g body weight were 0.99±0.23 or 0.85±0.30 (50 mg), 1.75±0.24 or 8.50±0.41 (100 mg), 2.07±0.60 or 8.40±0.39 (150 mg), respectively. Values in control animals were 0.51±0.07. As shown, the most marked increase in MB-CK levels is obtained at the 4th hour in 100 mg/100 g b.w. tyramine-treated rats. Thus MB-CK values were also explored at the 6th (7.43±0.15) and 12th (2.24±0.23) hours from drug administration. A significant (p
Databáze: OpenAIRE
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