A novel collagen area fraction index to quantitatively assess bowel fibrosis in patients with Crohn’s disease
| Autor: | Shi Ting Feng, Bao Lan Lu, Xuehua Li, Tian Ming Guan, Can Hui Sun, Jin jiang Lin, Qing Hua Cao, Ren Mao, Zhuang nian Fang, Zi Ping Li, Si Yun Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Area fraction
Crohn’s disease Adult Male medicine.medical_specialty Intraclass correlation Constriction Pathologic Gastroenterology Severity of Illness Index Masson's trichrome stain 03 medical and health sciences 0302 clinical medicine Crohn Disease Fibrosis Internal medicine Collagen fiber medicine Humans In patient lcsh:RC799-869 Correlation of Data Digestive System Surgical Procedures Crohn's disease Receiver operating characteristic business.industry General Medicine Hepatology medicine.disease digestive system diseases Intestines Research Design 030220 oncology & carcinogenesis lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology Female Collagen business Intestinal Obstruction Research Article |
| Zdroj: | BMC Gastroenterology BMC Gastroenterology, Vol 19, Iss 1, Pp 1-7 (2019) |
| ISSN: | 1471-230X |
| Popis: | Background A validated histopathological tool to precisely evaluate bowel fibrosis in patients with Crohn’s disease is lacking. We attempted to establish a new index to quantify the severity of bowel fibrosis in patients with Crohn’s disease-associated fibrostenosis. Methods We analyzed the histopathological data of 31 patients with Crohn’s disease strictures undergoing surgical resection. The most representative sections of resected strictured segments were stained with Masson trichrome to manifest bowel fibrosis. The collagen area fraction and histological fibrosis score were simultaneously calculated for the same section to evaluate the severity of bowel fibrosis. Results Collagen area fraction strongly correlated with histological fibrosis scores (r = 0.733, P (r = 0.561, P ) with the degree of bowel strictures than the histological fibrosis score did (r = 0.468, P P P P Conclusions Collagen area fraction is a simple and reliable index to quantify the severity of bowel fibrosis in patients with Crohn’s disease-associated fibrostenosis. |
| Databáze: | OpenAIRE |
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