An ivermectin tablet for sheep: efficacy against gastro-intestinal nematodes and a bioavailability comparison with a liquid ivermectin formulation
| Autor: | L G Cramer, W.K. Langholff, J.S. Eagleson, R P Gogolewski, G.R. Allerton |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Veterinary medicine animal diseases Helminthiasis Administration Oral Biological Availability Sheep Diseases Ivermectin Species Specificity Oral administration Helminths parasitic diseases medicine Parasite Egg Count Animals Anthelmintic Anthelmintics Sheep General Veterinary biology General Medicine medicine.disease biology.organism_classification Bioavailability Solutions Nematode Larva Parasitology Female Helminthiasis Animal Orchiectomy medicine.drug Gastro intestinal Tablets |
| Zdroj: | Veterinary parasitology. 60(3-4) |
| ISSN: | 0304-4017 |
| Popis: | An ivermectin tablet for oral administration to sheep was developed for use in countries where it is customary to treat sheep with anthelmintic tablets. Tablets require no special administration equipment, and offer convenience for storage and transport. The ivermectin tablet, which delivers 10 mg of ivermectin (200 micrograms kg-1 in a 50 kg sheep), had similar bioavailability to a liquid formulation of ivermectin (IVOMEC Liquid for Sheep) as determined by peak plasma ivermectin concentrations and area under the concentration curve in plasma (P0.10). In dose confirmation trials in which nematode infections were induced in helminth-naive sheep, animals treated with the ivermectin tablet had significantly fewer adult and fourth-stage larval nematodes than untreated control sheep (P0.01) with efficacies99% against all nematode species tested. In six field trials evaluating the efficacy of the ivermectin tablet in 240 Merino sheep, the reductions in faecal nematode egg counts ranged between 98 and 100%, as determined by comparison of pre- and post-treatment counts for the ivermectin-treated group. |
| Databáze: | OpenAIRE |
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