Serum thyroglobulin and 131I whole body scan after recombinant human TSH stimulation in the follow-up of low-risk patients with differentiated thyroid cancer
| Autor: | L. D'Aloiso, Sebastiano Filetti, Guido Valle, Vincenzo Frusciante, Vincenzo Trischitta, Anna Di Giorgio, Umberto Crocetti, Massimo Torlontano, Nazario Bonfitto, Sergio Modoni, Michele Bisceglia, Martin Schlumberger |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyrotropin Stimulation Carcinoma Papillary Follicular Thyroglobulin Metastasis Iodine Radioisotopes Endocrinology Risk Factors Internal medicine medicine Carcinoma Humans Thyroid Neoplasms Radionuclide Imaging Thyroid cancer Lymph node Aged Ultrasonography business.industry Thyroid General Medicine Middle Aged medicine.disease Recombinant Proteins medicine.anatomical_structure Female business Follow-Up Studies Hormone |
| Zdroj: | European Journal of Endocrinology. :19-24 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1480019 |
| Popis: | OBJECTIVE: The 'standard' postoperative follow-up of patients with differentiated thyroid cancer (DTC) has been based upon serum thyroglobulin (Tg) measurement and (131)I whole body scan ((131)I-WBS) after thyroid hormone (T(4)) treatment withdrawal. However, (131)I-WBS sensitivity has been reported to be low. Thyroid hormone withdrawal, often associated with hypothyroidism-related side effects, may now be replaced by recombinant human thyroid stimulating hormone (rhTSH). The aim of our study was to evaluate the diagnostic accuracy of (131)I-WBS and serum Tg measurement obtained after rhTSH stimulation and of neck ultrasonography in the first follow-up of DTC patients. DESIGN: Ninety-nine consecutive patients previously treated with total thyroidectomy and (131)I ablation, with no uptake outside the thyroid bed on the post-ablative (131)I-WBS (low-risk patients) were enrolled. METHODS: Measurement of serum Tg and (131)I-WBS after rhTSH stimulation, and ultrasound examination (US) of the neck. RESULTS: rhTSH-stimulated Tg was 1 ng/ml (Tg+) in 21 patients, including 6 patients with Tg levels >5 ng/ml. (131)I-WBS was negative for persistent or recurrent disease in all patients (i.e. sensitivity = 0%). US identified lymph-node metastases (confirmed at surgery) in 4/6 (67%) patients with stimulated Tg levels >5 ng/ml, in 2/15 (13%) with Tg>1 |
| Databáze: | OpenAIRE |
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