Reactive Oxygen Species-Responsive Polypeptide Drug Delivery System Targeted Activated Hepatic Stellate Cells to Ameliorate Liver Fibrosis

Autor:	Yumei Hao, Kaichao Song, Xiaochuan Tan, Ling Ren, Xiuping Guo, Chuchu Zhou, He Li, Jin Wen, Ya Meng, Mingbao Lin, Yujia Zhang, Hongdong Huang, Lulu Wang, Wensheng Zheng
Rok vydání:	2022
Předmět:	General Engineering General Physics and Astronomy General Materials Science
Zdroj:	ACS Nano. 16:20739-20757
ISSN:	1936-086X 1936-0851
DOI:	10.1021/acsnano.2c07796
Popis:	Hepatic fibrosis is a chronic liver disease that lacks effective pharmacotherapeutic treatments. As part of the disease's mechanism, hepatic stellate cells (HSCs) are activated by damage-related stimuli to secrete excessive extracellular matrix, leading to collagen deposition. Currently, the drug delivery system that targets HSCs in the treatment of liver fibrosis remains an urgent challenge due to the poor controllability of drug release. Since the level of reactive oxygen species (ROS) increases sharply in activated HSCs (aHSCs), we designed ROS-responsive micelles for the HSC-specific delivery of a traditional Chinese medicine, resveratrol (RES), for treatment of liver fibrosis. The micelles were prepared by the ROS-responsive amphiphilic block copolymer poly(l-methionine
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e591ef6f1415175e0a80168797f23eba https://doi.org/10.1021/acsnano.2c07796 Zobrazit plný text záznamu