Mapping IPF helps identify geographic regions at higher risk for disease development and potential triggers
| Autor: | María Teresa Pay, Inma Salvador, Amalia Moreno, Pilar Rivera-Ortega, Jordi Sans, Claudia Guevara, Damià Perich, Saioa Eizaguirre Anton, Jacobo Sellares, Maria Molina-Molina, Roger Llatjós, Enric Barbeta, Maria Guadalupe Silveira, Vanesa Vicens-Zygmunt, Jordi Dorca, Patricio Luburich, Jaume Bordas-Martinez, Carla Lara Compte, Karina Portillo, Ana Villar, Guillermo Suarez-Cuartin, Jessica Shull, Alejandro Robles-Perez, Diana Badenes-Bonet, M Josefa Cardona, Eva Balcells, Rosa Jolis, Jordi Esplugas, Diego Castillo, Leonardo Esteban, Lurdes Planas-Cerezales, Oriol Jorba, Rosana Blavia, Antoni Rosell, Laia Garcia-Bellmunt, Miriam Olid, Silvia Barril, Guadalupe Bermudo |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty air pollution Disease 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine Air Pollution Environmental health Epidemiology Humans Medicine Prospective Studies 030212 general & internal medicine Prospective cohort study Air quality index Retrospective Studies Air Pollutants geographic region business.industry Retrospective cohort study environmental risk factor respiratory system medicine.disease idiopathic pulmonary fibrosis Idiopathic Pulmonary Fibrosis humanities respiratory tract diseases 030228 respiratory system Geographic regions Observational study business early diagnosis |
| Zdroj: | RESPIROLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Fundacion Sancho el Sabio Fundazioa (FSS) Respirology r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname |
| ISSN: | 1323-7799 |
| Popis: | Background and objective The relationship between IPF development and environmental factors has not been completely elucidated. Analysing geographic regions of idiopathic pulmonary fibrosis (IPF) cases could help identify those areas with higher aggregation and investigate potential triggers. We hypothesize that cross-analysing location of IPF cases and areas of consistently high air pollution concentration could lead to recognition of environmental risk factors for IPF development. Methods This retrospective study analysed epidemiological and clinical data from 503 patients registered in the Observatory IPF.cat from January 2017 to June 2019. Incident and prevalent IPF cases from the Catalan region of Spain were graphed based on their postal address. We generated maps of the most relevant air pollutant PM2.5 from the last 10 years using data from the CALIOPE air quality forecast system and observational data. Results In 2018, the prevalence of IPF differed across provinces; from 8.1 cases per 100 000 habitants in Barcelona to 2.0 cases per 100 000 in Girona. The ratio of IPF was higher in some areas. Mapping PM2.5 levels illustrated that certain areas with more industry, traffic and shipping maintained markedly higher PM2.5 concentrations. Most of these locations correlated with higher aggregation of IPF cases. Compared with other risk factors, PM2.5 exposure was the most frequent. Conclusion In this retrospective study, prevalence of IPF is higher in areas of elevated PM2.5 concentration. Prospective studies with targeted pollution mapping need to be done in specific geographies to compile a broader profile of environmental factors involved in the development of pulmonary fibrosis. |
| Databáze: | OpenAIRE |
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