Current trends in mouse models of glioblastoma
| Autor: | Toru Iwama, Masafumi Miyai, Hiroyuki Tomita, Akio Soeda, Hirohito Yano, Akira Hara |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Pathology medicine.medical_specialty Mouse Angiogenesis Cell Brain tumor Disease Biology medicine.disease_cause 03 medical and health sciences Mice Glioma medicine Animals Humans neoplasms High rate Brain Neoplasms Xenograft medicine.disease nervous system diseases Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neurology Oncology Cancer research Neurology (clinical) Topic Review Carcinogenesis Glioblastoma |
| Zdroj: | Journal of Neuro-Oncology |
| ISSN: | 1573-7373 |
| Popis: | Glioblastoma is the most deadly brain tumor type and is characterized by a severe and high rate of angiogenesis, remaining an incurable disease in the majority of cases. Mechanistic understanding of glioblastoma initiation and progression is complicated by the complexity of genetic and/or environmental initiating events and lack of clarity regarding the cell or tissue of origin. To determine these mechanisms, mouse models that recapitulate the molecular and histological characteristics of glioblastoma are required. Unlike in other malignancies, viral-mediated mouse models of glioblastoma rather than chemically induced mouse models have been developed because of its sensitivity to viruses. Based on recent molecular analyses reported for human glioblastoma, this review critically evaluates genetically engineered, xenograft, allograft, viral-mediated, and chemically induced mouse models of glioblastoma. Further, we focus on the clinical value of these models by examining their contributions to studies of glioblastoma prevention, tumorigenesis, and chemoresistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink