Protective effects of trapidil in ischemia-reperfusion injury due to testicular torsion and detorsion: An experimental study
| Autor: | Sibel Erdogan, Osman Caglayan, Hülya Akman, Salih Somuncu, Murat Çakmak, Murat Kaya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
endocrine system Testicular tissue Urology An experimental study- INTERNATIONAL JOURNAL OF UROLOGY cilt.13 ss.601-605 2006 [Somuncu S. Cakmak M. Erdogan S. Caglayan O. Akman H. Kaya M. -Protective effects of trapidil in ischemia-reperfusion injury due to testicular torsion and detorsion] ischemia-reperfusion injury Ischemia Trapidil Nitric Oxide Nitric oxide testis torsion-detorsion chemistry.chemical_compound free oxygen radicals Malondialdehyde trapidil medicine otorhinolaryngologic diseases Testicular torsion Animals Sulfhydryl Compounds Rats Wistar Spermatic Cord Torsion business.industry medicine.disease Left Testis Rats body regions Disease Models Animal chemistry Anesthesia Reperfusion Injury biological sciences business Reperfusion injury medicine.drug |
| ISSN: | 0002-3760 |
| Popis: | WOS: 000237600700020 PubMed: 16771732 Objective: We aimed to detect the preventive effects of trapidil in ischemia reperfusion (IR) injury due to testicular torsion and detorsion. Methods: Forty prepubertal albino rats were used. In the IR group, torsion was created by rotating the left testis over 2 h, and detorsion was done by untwisting the testis. Bilateral orchiectomies were performed after 4 h. In study group, 2-h torsion was performed and trapidil was administered as a single dose I h before detorsion. Bilateral orchiectomies were performed after 4 h. In the sham group, a sham operation was done. In the sham plus trapidil group, a sham operation was done and trapidil was administered as a single dose. Testicular tissue malondialdehyde (MDA), nitric oxide (NO) and total sulfhydryl (T-SH) levels were determined for each group. The grades of interstitial injury were determined in histopathologic examination. Results: The NO and MDA levels in the IR group were significantly higher than the study, sham and sham plus trapidil groups in the left testis (P < 0.05 P < 0.001 and P < 0.001, respectively). A statistical difference was not found among Study, sham and sham plus trapidil groups in the left testis in NO and MDA levels (P > 0.05). The T-SH level in the study group was significantly higher than in the IR. sham and sham plus trapidil groups in left testis P < 0.05). In the IR group (left testis), grade I interstitial injury was 30% (3/10), grade 2 injury was 60% (6/10) and grade 3 injury was 10% (1/10). In the study group (left testis), grade I interstitial injury was 30% (3/10) and there was no injury in 70% (7/10). Conclusion: Trapidil decreased free oxygen radical formation in testicular torsion and detorsion, and attenuated histopathological damage in the ipsilateral twisted testis. |
| Databáze: | OpenAIRE |
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