Gastric Ganglioneuroblastoma
| Autor: | Claudio Sandoval, S Oiseth, Oya Tugal, M. F. Ozkaynak, Somasundaram Jayabose, Michel Slim, Adele Brudnicki, Howard E. Bostwick, Debra Beneck |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Vincristine
Pathology medicine.medical_specialty medicine.medical_treatment Mediastinal tumor Neoplasms Multiple Primary Stomach Neoplasms Neuroblastoma Laparotomy medicine Humans Stage (cooking) Etoposide Ganglioneuroblastoma business.industry Stomach Infant Hematology medicine.disease medicine.anatomical_structure Oncology Gastric Mucosa Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 18:409-412 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/00043426-199611000-00016 |
| Popis: | Purpose: This report describes a female infant with stage 4 multifocal ganglioneuroblastoma with gastric involvement. Patient: The patient had a right cervical tumor, a left posterior mediastinal tumor, bilateral adrenal tumors, and bony and bone marrow metastases. The tumor cells were diploid and lacked N-myc gene amplification. The gastric involvement, which did not produce clinical symptoms, was only detected by meticulous exploration during laparotomy. Results: Our patient achieved only a partial response to alternating cycles of cyclophosphamide, vincristine, and adriamycin; and etoposide and cisplatin. She currently has stable, unresectable disease with elevated catecholamines. Conclusions: Multifocal ganglioneuroblastomas may arise from either neuroblastic rests or aberrant deposits of neuroblasts. The latter mechanism may have accounted for our patient's gastric tumor. Patients with multifocal ganglioneuroblastomas warrant meticulous radiographic and surgical evaluation to completely document the full extent of disease, and to ensure appropriate staging and therapy. |
| Databáze: | OpenAIRE |
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