Clinical warning of hemophagocytic syndrome caused by Epstein-Barr virus
| Autor: | Yixue Yu, Weifang Zhou, Chu Chu, Yali Luo, Min Yu, Jinjin Shi, Dandan Zhang, Yuqin Li, Yujie Fan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Herpesvirus 4 Human Mononucleosis CD3 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology Sensitivity and Specificity Virus Lymphohistiocytosis Hemophagocytic 03 medical and health sciences 0302 clinical medicine Internal medicine hemic and lymphatic diseases D-dimer Medicine Humans Infectious Mononucleosis Risk factor Retrospective Studies biology business.industry Research EBV DNA load lcsh:RJ1-570 Infant lcsh:Pediatrics Viral Load medicine.disease Epstein–Barr virus Ebv infection Hospitalization Child Preschool biology.protein Female Symptom Assessment business Hemophagocytic syndrome 030217 neurology & neurosurgery CD8 |
| Zdroj: | Italian Journal of Pediatrics Italian Journal of Pediatrics, Vol 47, Iss 1, Pp 1-7 (2021) |
| ISSN: | 1824-7288 |
| Popis: | Objectives This study aimed to compare the clinical features and laboratory tests of infectious mononucleosis (IM) and hemophagocytic syndrome (HLH) caused by Epstein-Barr virus (EBV) in 1–3-year-old children and to explore the risk factor of HLH caused by EBV (EBV-HLH). Methods The clinical data of 92 children with EBV infection admitted in our hospital from 2011 to 2019 were collected; 61 cases were diagnosed as EBV-IM, and 31 cases were diagnosed as EBV-HLH. The subjects’ clinical manifestations and laboratory tests were analyzed retrospectively. Results Compared with EBV-IM patients, EBV-HLH patients had longer durations of fever, both before hospitalization and overall, and a higher probability of hepatomegaly. The levels of ALT, AST, LDH, TG, SF, D-Dimer and the plasma EBV DNA load of EBV-HLH patients were significantly higher than those of EBV-IM patients. The absolute values of CD3+, CD4+, CD8+, NK, and CD3-CD19+ cells and IgA and IgM levels of EBV-HLH patients were significantly lower than those of EBV-IM patients. The plasma EBV DNA load was positively correlated with the PT, TT, α-HBDH, AST, LDH, CK, Scr, BUN, UA, TG, and CRP levels in EBV-HLH patients, and the plasma EBV DNA load was positively correlated with the D-Dimer level in the EBV-IM patients. Among the 10 different potential markers, at the cut-off point of 1721.500 μg/L, the sensitivity and specificity of D-Dimer was 88.90 and 90.20%, respectively. Conclusion The D-Dimer level may be a good prognostic indicator of EBV-HLH caused by EBV. |
| Databáze: | OpenAIRE |
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