A Novel Monoclonal Antibody Induces Cancer Cell Apoptosis and Enhances the Activity of Chemotherapeutic Drugs
| Autor: | Bo Ying Dun, Guangkuo Dong, Jin-Xiong She, Heng Xu, Jinhua Wang, Yanna Tian, Haitao Liu, Bo Chen, Shang Su Lu |
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| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Epidemiology medicine.drug_class medicine.medical_treatment Antineoplastic Agents Apoptosis Monoclonal antibody Cell Line Mice Cell Line Tumor medicine Carcinoma Animals Humans Cell Proliferation Mice Inbred BALB C Chemotherapy biology Cell growth Chemistry Public Health Environmental and Occupational Health Antibodies Monoclonal Cancer medicine.disease Molecular biology Oncology Cell culture biology.protein Antibody HeLa Cells |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:4423-4428 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2014.15.11.4423 |
| Popis: | A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy. |
| Databáze: | OpenAIRE |
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