Assessment of the Role of 1,3-β-d-Glucan Testing for the Diagnosis of Invasive Fungal Infections in Adults
| Autor: | Zdenek Racil, O. Marchetti, Mario Cruciani, Frédéric Lamoth, Luis Ostrosky-Zeichner, Hamdi Akan, Cornelius J. Clancy, David R. Andes |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty Hematologic cancer beta-Glucans business.industry Clinical settings Invasive candidiasis Aspergillosis medicine.disease Intensive care unit Sensitivity and Specificity law.invention Patient population Infectious Diseases law Intensive care Internal medicine medicine Humans Candidiasis Invasive business 1 3 β d glucan Glucans Invasive Fungal Infections |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 72(Suppl 2) |
| ISSN: | 1537-6591 |
| Popis: | Detection of 1,3-β-d-glucan (BDG) in serum has been evaluated for its inclusion as a mycological criterion of invasive fungal infections (IFI) according to EORTC and Mycoses Study Group (MSG) definitions. BDG testing may be useful for the diagnosis of both invasive aspergillosis and invasive candidiasis, when interpreted in conjunction with other clinical/radiological signs and microbiological markers of IFI. However, its performance and utility vary according to patient population (hematologic cancer patients, solid-organ transplant recipients, intensive care unit patients) and pretest likelihood of IFI. The objectives of this article are to provide a systematic review of the performance of BDG testing and to assess recommendations for its use and interpretation in different clinical settings. |
| Databáze: | OpenAIRE |
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