Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)

Autor:	Danielle J. Vugts, Margherita Vaselli, Carla F. M. Molthoff, Helene Knaus, Valentina Davidoiu, Fabio Feroldi, Guus A.M.S. van Dongen, Johannes F. de Boer, Mariska Verlaan
Přispěvatelé:	Biophotonics and Medical Imaging, LaserLaB - Biophotonics and Microscopy, Amsterdam Neuroscience - Brain Imaging
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.diagnostic_test Optical coherence tomography SDG 3 - Good Health and Well-being Positron emission tomography Computer science medicine Cancer therapy Structural context Molecular imaging Intraoperative imaging Biomedical engineering
Zdroj:	Feroldi, F, Vaselli, M, Verlaan, M, Knaus, H, Davidoiu, V, Vugts, D, Molthoff, C, van Dongen, G & de Boer, J F 2020, ' Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation) ', Paper presented at SPIE BiOS 2020, San Francisco, United States, 1/02/20-6/02/20 . https://doi.org/10.1117/12.2545222 SPIE BiOS 2020
DOI:	10.1117/12.2545222
Popis:	Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission tomography, this feat is currently not achievable. Here, we demonstrate that revealing the TME is possible with immuno-near-infrared-fluorescence (Immuno-NIRF) imaging. Moreover, we combined immuno-NIRF with optical coherence tomography (OCT) to provide structural context to the molecular images. The combination of the two techniques may represent a novel tool in the operating room for assessing development or early diagnosis of tumors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58a6a7d34cae71c195dcdb29b822645 https://doi.org/10.1117/12.2545222 Zobrazit plný text záznamu