Pediatric acute lymphoblastic leukemia with a t(8;14)(q11.2;q32): B-cell disease with a high proportion of Down syndrome: a Children's Oncology Group study
| Autor: | Yoav H. Messinger, Meenakshi Devidas, Andrew J. Carroll, Nyla A. Heerema, Rodney R. Higgins, Stephen P. Hunger |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Down syndrome Adolescent Population Chromosomal translocation Kaplan-Meier Estimate Biology Philadelphia chromosome Disease-Free Survival Translocation Genetic Article Cog Precursor B-Cell Lymphoblastic Leukemia-Lymphoma hemic and lymphatic diseases Internal medicine Genetics medicine Humans Child education Molecular Biology B cell Chromosomes Human Pair 14 education.field_of_study Cytogenetics medicine.disease Treatment Outcome medicine.anatomical_structure Child Preschool Concomitant Cytogenetic Analysis Female Down Syndrome Chromosomes Human Pair 8 |
| Zdroj: | Cancer Genetics. 205:453-458 |
| ISSN: | 2210-7762 |
| Popis: | The rare translocation t(8;14)(q11.2;q32) has been described in patients with B-cell acute lymphoblastic leukemia (ALL), particularly patients with Down syndrome (DS). We describe patients with the t(8;14)(q11.2;q32) who were identified by the Children's Oncology Group (COG) ALL cytogenetics database, expanding our previous report of 10 patients with this translocation. Twenty-two such patients were treated with COG protocols. All patients had B-cell ALL, and seven (31.8%) had DS. None of the children with DS had an event; thus, these patients had a superior estimated 5-year event-free survival (EFS) compared to non-DS patients (100% vs. 50.1 ± 17.7%; P = 0.04). Only one patient (4.5%) had a concomitant Philadelphia chromosome t(9;22)(q34;q11.2). The cytogenetics data of two additional patients, who were not eligible for COG protocols, are also included in this report. In conclusion, ALL patients with the recurring translocation t(8;14)(q11.2;q32) have the B-cell phenotype and a high percentage have DS. Children with DS and the t(8;14)(q11.2;q34) have improved EFS using standard COG therapy compared to non-DS patients. We did not find an increased number of patients with a concomitant Philadelphia chromosome in this population. |
| Databáze: | OpenAIRE |
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