Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality
| Autor: | Clayton Bennett, Daniel J. Moore, Ryan Loveland, Riet van der Meer, James L. Wynn, John T. Benjamin, Ashley Royce |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Sepsis mortality Inflammatory response Immunology Interleukin-1beta Inflammation Article Sepsis 03 medical and health sciences Paracrine signalling Mice 0302 clinical medicine Mediator Interleukin-1alpha medicine Immunology and Allergy Animals Humans Receptor Receptors Interleukin-1 Type I business.industry Infant Newborn medicine.disease Mice Inbred C57BL 030104 developmental biology Animals Newborn Lethality Female medicine.symptom business 030215 immunology Signal Transduction |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 201(10) |
| ISSN: | 1550-6606 |
| Popis: | Sepsis disproportionately affects the very old and the very young. IL-1 signaling is important in innate host defense but may also play a deleterious role in acute inflammatory conditions (including sepsis) by promulgating life-threatening inflammation. IL-1 signaling is mediated by two distinct ligands: IL-1α and IL-1β, both acting on a common receptor (IL-1R1). IL-1R1 targeting has not reduced adult human sepsis mortality despite biologic plausibility. Because the specific role of IL-1α or IL-1β in sepsis survival is unknown in any age group and the role of IL-1 signaling remains unknown in neonates, we studied the role of IL-1 signaling, including the impact of IL-1α and IL-1β, on neonatal murine sepsis survival. IL-1 signaling augments the late plasma inflammatory response to sepsis. IL-1α and not IL-1β is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue. These data do not support targeting IL-1 signaling in neonates. |
| Databáze: | OpenAIRE |
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