Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women
| Autor: | Liz Maria, de Almeida, Sandra, Cortés, Marta, Vilensky, Olivia, Valenzuela, Laura, Cortes-Sanabria, Mirian, de Souza, Rafael Alonso, Barbeito, Eliana, Abdelhay, Nora, Artagaveytia, Adrian, Daneri-Navarro, Andrea S, Llera, Bettina, Müller, Osvaldo L, Podhajcer, Carlos, Velazquez, Elsa, Alcoba, Isabel, Alonso, Alicia I, Bravo, Natalia, Camejo, Dirce Maria, Carraro, Mónica, Castro, Sandra, Cataldi, Alfonso, Cayota, Mauricio, Cerda, Alicia, Colombo, Susanne, Crocamo, Alicia, Del Toro-Arreola, Raul, Delgadillo-Cristerna, Lucia, Delgado, Marisa Dreyer, Breitenbach, Elmer, Fernández, Jorge, Fernández, Wanda, Fernández, Ramon A, Franco-Topete, Fancy, Gaete, Jorge, Gómez, Leivy P, Gonzalez-Ramirez, Marisol, Guerrero, Susan A, Gutierrez-Rubio, Beatriz, Jalfin, Alejandra, Lopez-Vazquez, Dora, Loria, Silvia, Míguez, Andres de J, Moran-Mendoza, Gilberto, Morgan-Villela, Carina, Mussetti, Maria Aparecida, Nagai, Antonio, Oceguera-Villanueva, Rui M, Reis, Javier, Retamales, Robinson, Rodriguez, Cristina, Rosales, Efrain, Salas-Gonzalez, Laura, Segovia, Juan M, Sendoya, Aida A, Silva-Garcia, Stella, Viña, Livia, Zagame, Beth, Jones, Moysés, Szklo, Zdenka, Zlatar |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | de Almeida, Liz María, Cortés, Sandra ORCID: https://orcid.org/0000-0003-3293-1419 |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2022.845527 |
| Popis: | Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity. Copyright © 2022 de Almeida, Cortés, Vilensky, Valenzuela, Cortes-Sanabria, de Souza, Barbeito, Abdelhay, Artagaveytia, Daneri-Navarro, Llera, Müller, Podhajcer, Velazquez, Alcoba, Alonso, Bravo, Camejo, Carraro, Castro, Cataldi, Cayota, Cerda, Colombo, Crocamo, Del Toro-Arreola, Delgadillo-Cristerna, Delgado, Breitenbach, Fernández, Fernández, Fernández, Franco-Topete, Gaete, Gómez, Gonzalez-Ramirez, Guerrero, Gutierrez-Rubio, Jalfin, Lopez-Vazquez, Loria, Míguez, Moran-Mendoza, Morgan-Villela, Mussetti, Nagai, Oceguera-Villanueva, Reis, Retamales, Rodriguez, Rosales, Salas-Gonzalez, Segovia, Sendoya, Silva-Garcia, Viña, Zagame, Jones, Szklo and United States-Latin American Cancer Research Network (US-LACRN). Fil: de Almeida, Liz Maria. Instituto Nacional de Cáncer; Brasil Fil: Cortés, Sandra. Pontificia Universidad Católica de Chile; Chile Fil: Vilensky, Marta. Instituto de Oncología Angel Roffo; Argentina Fil: Valenzuela, Olivia. Universidad de Sonora; México Fil: Cortes-Sanabria, Laura. Hospital de Especialidades, CMNO-IMSS; México Fil: de Souza, Mirian. Instituto Nacional de Cáncer; Brasil Fil: Barbeito, Rafael Alonso. Facultad de Medicina; Argentina Fil: Abdelhay, Eliana. Instituto Nacional de Cáncer; Brasil Fil: Artagaveytia, Nora. Hospital de Clínicas Manuel Quintela. Universidad de la República; Uruguay Fil: Daneri-Navarro, Adrian. Universidad de Guadalajara; México Fil: Llera, Andrea S. CONICET. Fundación Instituto Leloir; Argentina Fil: Müller, Bettina. Instituto Nacional del Cáncer; Argentina Fil: Podhajcer, Osvaldo L. CONICET. Fundación Instituto Leloir; Argentina Fil: Velazquez, Carlos. Universidad de Sonora; México Fil: Alcoba, Elsa. Hospital Municipal de Oncología María Curie; Argentina Fil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; Argentina Fil: Bravo, Alicia I. Hospital Regional de Agudos Eva Perón; Argentina Fil: Camejo, Natalia. Hospital de Clínicas Manuel Quintela. Universidad de la República; Uruguay Fil: Carraro, Dirce Maria. AC Camargo Cancer Center; Brasil Fil: Castro, Mónica. Instituto de Oncología Angel Roffo; Argentina Fil: Cataldi, Sandra. Instituto Nacional de Cáncer; Uruguay Fil: Cayota, Alfonso. Institut Pasteur de Montevideo; Uruguay Fil: Cerda, Mauricio. Universidad de Chile; Chile Fil: Colombo, Alicia. Universidad de Chile; Chile Fil: Crocamo, Susanne. Instituto Nacional de Cáncer; Brasil Fil: Del Toro-Arreola, Alicia. Universidad de Guadalajara; México Fil: Delgadillo-Cristerna, Raul. Hospital de Especialidades. CMNO-IMSS; México Fil: Delgado, Lucia. Hospital de Clínicas Manuel Quintela; Uruguay Fil: Breitenbach, Marisa Dreyer. Universidade do Estado do Rio de Janeiro; Brasil Fil: Fernández, Elmer. Universidad Católica de Córdoba. CONICET. Centro de Investigaciones en Bioquímica Clínica e Inmunologia; Argentina Fil: Fernández, Jorge. Instituto de Salud Pública; Chile Fil: Fernández, Wanda. Hospital San Borja Arriarán; Chile Fil: Franco-Topete, Ramon A. OPD Hospital Civil de Guadalajara. Universidad de Guadalajara; México Fil: Gaete, Fancy. Hospital Luis Tisne; Chile Fil: Gómez, Jorge. Texas A&M University; Estados Unidos Fil: Gonzalez-Ramirez, Leivy P. Universidad de Guadalajara; México Fil: Guerrero, Marisol. Hospital San José; Chile Fil: Gutierrez-Rubio, Susan A. Universidad de Guadalajara; México Fil: Jalfin, Beatriz. Hospital Regional de Agudos Eva Perón; Argentina Fil: Lopez-Vazquez, Alejandra. Universidad de Sonora; México Fil: Loria, Dora. Instituto de Oncología Angel Roffo; Argentina Fil: Míguez, Silvia. Hospital Municipal de Oncología María Curie; Argentina Fil: Moran-Mendoza, Andres de J. Hospital de Gineco-Obstetricia CMNO-IMSS; México Fil: Morgan-Villela, Gilberto. Hospital de Especialidades. CMNO-IMSS; México Fil: Mussetti, Carina. Registro Nacional de Cancer; Uruguay Fil: Nagai, Maria Aparecida. Instituto de Câncer de São Paulo; Brasil Fil: Oceguera-Villanueva, Antonio. Instituto Jalisciense de Cancerologia; México Fil: Reis, Rui M. Hospital de Câncer de Barretos; Brasil Fil: Retamales, Javier. Grupo Oncológico Cooperativo Chileno de Investigación; Chile Fil: Rodriguez, Robinson. Hospital Central de las Fuerzas Armadas; Uruguay Fil: Rosales, Cristina, Hospital Municipal de Oncología María Curie; Argentina Fil: Salas-Gonzalez, Efrain. Hospital San José; Chile Fil: Segovia, Laura. Hospital Barros Luco Trudeau; Chile Fil: Sendoya, Juan M. CONICET. Fundación Instituto Leloir,; Argentina Fil: Silva-Garcia, Aida A. OPD Hospital Civil de Guadalajara. Universidad de Guadalajara; México Fil: Viña, Stella. Instituto de Oncología Angel Roffo; Argentina Fil: Zagame, Livia. Instituto Jalisciense de Cancerologia; México Fil: Jones, Beth. Yale University. Yale School of Public Health; Estados Unidos Fil: Szklo, Moysés. Johns Hopkins University. Johns Hopkins Bloomberg School of Public Health; Estados Unidos |
| Databáze: | OpenAIRE |
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