Abstinence after First Acute Alcohol-Associated Pancreatitis Protects Against Recurrent Pancreatitis and Minimizes the Risk of Pancreatic Dysfunction
| Autor: | Sari Räty, Hanna Seppänen, Johanna Laukkarinen, Juhani Sand, Riitta Lappalainen-Lehto, Isto Nordback, Jussi Nikkola, Satu Järvinen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Alcohol Drinking Pancreatitis Alcoholic media_common.quotation_subject Gastroenterology Recurrent pancreatitis Diabetes mellitus Internal medicine Secondary Prevention medicine Humans Pancreatitis chronic media_common Alcohol Use Disorders Identification Test business.industry Alcohol dependence General Medicine Abstinence medicine.disease Surgery Pancreatic Function Tests medicine.anatomical_structure Acute Disease Pancreatitis business Pancreas Follow-Up Studies |
| Zdroj: | Alcohol and Alcoholism. 48:483-486 |
| ISSN: | 1464-3502 0735-0414 |
| DOI: | 10.1093/alcalc/agt019 |
| Popis: | To determine the recurrence of pancreatitis and subsequent pancreatic function in patients who stop drinking after the first episode of alcohol-associated pancreatitis.Of a total of 118 patients suffering from their first alcohol-associated pancreatitis, 18 (all men, age median 47 (27-71) years) met the inclusion criterion for abstinence during follow-up. The criterion for abstinence was alcohol consumption24 g per 2 months (self-estimated), which is in line with questionnaires eliciting alcohol consumption and dependency (Alcohol Use Disorders Identification Test8 and Short Alcohol Dependence Data9). Recurrent attacks of acute pancreatitis were studied. Smoking, body mass index and laboratory tests detecting heavy consumption of alcohol were recorded. Blood and faecal tests were studied to assess endocrine and exocrine pancreatic function.During a mean follow-up time of 5.15 (1.83-9.13) years and a total of 92.7 patient-years, there were no recurrent attacks of acute pancreatitis among the 18 abstainers. Two patients had diabetes prior to and one was diagnosed immediately after the first episode of acute pancreatitis. One patient had impaired glucose metabolism at 2 years. Two patients had low insulin secretion in glucagon-C-peptide test, one at 4 years and the other at 5 years. Only one patient (6%) maintained low elastase-1 activity during the abstinence follow-up. Of the 100 non-abstainers, 34% had at least one recurrence during the follow-up.Regardless of the mediator mechanisms of acute alcoholic pancreatitis, abstinence after the first episode protects against recurrent attacks. Pancreatic dysfunction is also rare among abstinent patients. |
| Databáze: | OpenAIRE |
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