Prognostic and clinicopathological significance of Fusobacterium nucleatum in colorectal cancer: a systemic review and meta-analysis

Autor:	Younghoon Kim, Nam Yun Cho, Gyeong Hoon Kang
Rok vydání:	2022
Předmět:	Histology Pathology and Forensic Medicine
Zdroj:	Journal of Pathology and Translational Medicine. 56:144-151
ISSN:	2383-7845 2383-7837
DOI:	10.4132/jptm.2022.03.13
Popis:	Background: Fusobacterium nucleatum has been identified to promote tumor progression in colorectal cancer (CRC). However, association between F. nucleatum and prognostic or clinicopathological features has been diverse among studies, which could be affected by type of biospecimen (formalin-fixed paraffin-embedded or fresh frozen [FF]).Methods: Articles were systemically reviewed for studies that included the correlation between F. nucleatum and prognosis or clinicopathological features in CRC.Results: Ten articles, eight studies with survival-related features involving 3,199 patients and nine studies with clinical features involving 2,655 patients, were eligible for the meta-analysis. Overall survival, disease-free survival, and cancer-specific survival were all associated with worse prognosis in F. nucleatum–high patients (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e584649e7c2c68a529edea2047b91247 https://doi.org/10.4132/jptm.2022.03.13 Zobrazit plný text záznamu