Alimentary lipemia-induced redistribution of cholesteryl ester between lipoproteins. Studies in normolipidemic, combined hyperlipidemic, and hypercholesterolemic men
| Autor: | W J Sluiter, J E Groener, D W Erkelens, Robin P. F. Dullaart, H van Wijk |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Lipoproteins Hypercholesterolemia Hyperlipidemias chemistry.chemical_compound High-density lipoprotein In vivo Internal medicine Cholesterylester transfer protein polycyclic compounds medicine Humans Triglycerides Glycoproteins Intermediate-density lipoprotein Total plasma biology Dietary Fats Lipids Cholesterol Ester Transfer Proteins Endocrinology chemistry Biochemistry Low-density lipoprotein biology.protein Cholesteryl ester lipids (amino acids peptides and proteins) Cholesterol Esters Carrier Proteins Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Arteriosclerosis: An Official Journal of the American Heart Association, Inc.. 9:614-622 |
| ISSN: | 0276-5047 |
| DOI: | 10.1161/01.atv.9.5.614 |
| Popis: | Alimentary lipemia stimulates the transfer of cholesteryl ester between lipoproteins in vitro and may alter lipoprotein cholesteryl ester distribution in vivo. The effect of a single, large oral fat load on lipoprotein cholesteryl ester redistribution and the activity of cholesteryl ester transfer protein was investigated in six normolipidemic men (Group A), six combined hyperlipidemic men (Group B), and six hypercholesterolemic men (Group C). Fasting triglyceride-rich lipoprotein cholesteryl ester was high in Group B, low in Group A, and intermediate in Group C (A less than C less than B, p less than 0.05). After an oral fat load, total plasma cholesteryl ester was unchanged in all groups. In Group A, cholesteryl ester increased in smaller triglyceride-rich lipoproteins and remained so at 24 hours. Conversely, low density and high density lipoprotein cholesteryl ester decreased and returned to fasting values at 24 hours. In Group B, cholesteryl ester increased in large triglyceride-rich lipoproteins. Low density and high density lipoprotein cholesteryl ester (expressed as percentage of plasma cholesteryl ester) decreased. By contrast, in Group C, triglyceride-rich lipoprotein and low density lipoprotein cholesteryl ester remained unaltered, and only high density lipoprotein cholesteryl ester decreased. The activity of cholesteryl ester transfer protein increased in all groups and returned to fasting values at 24 hours. No differences in response were observed among the three groups. It is concluded that an oral fat load can induce a shift in lipoprotein cholesteryl ester distribution from high and low density lipoproteins to triglyceride-rich lipoproteins without affecting total plasma cholesteryl ester.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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