Effect of low-dose atropine eyedrops on pupil metrics: results after half a year of treatment and cessation

Autor: Wei-Ling Bai, Jia-He Gan, Shifei Wei, Shi-Ming Li, Wen-Zai An, Xin-Tong Liang, Jia-Xin Tian, Lei Yin, Ningli Wang
Rok vydání: 2022
Předmět:
Zdroj: Graefe's Archive for Clinical and Experimental Ophthalmology. 261:1177-1186
ISSN: 1435-702X
0721-832X
DOI: 10.1007/s00417-022-05863-8
Popis: Purpose To evaluate the effect of low-dose atropine eyedrops on pupil metrics. Methods This study was based on a randomized, double-masked, placebo-controlled, and cross-over trial in mainland China. In phase 1, subjects received 0.01% atropine or placebo once nightly. After 1 year, the atropine group switched to placebo (atropine-placebo group), and the placebo group switched to atropine (placebo-atropine group). Ocular parameters were measured at the crossover time point (at the 12th month) and the 18th month. Results Of 105 subjects who completed the study, 48 and 57 children were allocated into the atropine-placebo and placebo-atropine groups, respectively. After cessation, the photopic pupil diameter (PD) and mesopic PD both decreased (− 0.46 ± 0.47 mm, P P = 0.008), and the constriction ratio (CR, %) increased (4.39 ± 7.54, P P P P Conclusion Pupil metrics and the CR could return to pre-atropine levels after cessation. Pupil metrics had no significant effect on myopia progression during treatment.
Databáze: OpenAIRE
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