Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women
| Autor: | Lauren W. Roth, Erica L. Bradshaw-Pierce, Amanda A. Allshouse, Nanette Santoro, Wendy M. Kohrt, Jennifer Lesh, Andrew P. Bradford, Justin Chosich, Alex J. Polotsky |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism media_common.quotation_subject Luteal Phase Luteal phase Article Young Adult Follicle-stimulating hormone Endocrinology Internal medicine Humans Medicine Obesity Menstrual cycle media_common business.industry Hypogonadism Luteinizing Hormone Pharmacodynamics Female Follicle Stimulating Hormone business Luteinizing hormone hormones hormone substitutes and hormone antagonists Hypogonadotrophic hypogonadism Hormone Blood sampling |
| Zdroj: | Clinical Endocrinology. 81:418-425 |
| ISSN: | 0300-0664 |
| Popis: | SummaryObjectives Female obesity is a state of relative hypogonadotrophic hypogonadism. The aim of this study is to examine gonadotrophin secretion and response to gonadotrophin-releasing hormone (GnRH) in the luteal phase of the menstrual cycle and to investigate the pharmacodynamics and pharmacokinetics of endogenous and exogenous luteinizing hormone (LH) in obese women. Design Participants underwent a luteal phase frequent blood sampling study. Endogenous LH pulsatility was observed, gonadotrophin-releasing hormone (GnRH) was given in two weight-based doses, and GnRH antagonist was administered followed by recombinant LH. Patients Regularly menstruating obese (n = 10) and normal weight (n = 10) women. Measurements Endogenous hypothalamic-pituitary function (as measured by LH pulsatility), pituitary sensitivity (GnRH-induced LH secretion), pharmacodynamics of endogenous LH and pharmacokinetics of exogenous LH were compared between the obese and normal weight groups. Results There were no statistically significant differences in endogenous LH pulsatility or pituitary responses to two weight-based doses of GnRH between the obese and normal weight women. There were no differences in the pharmacodynamics of endogenous LH or the pharmacokinetics of exogenous LH between the groups. FSH dynamics did not differ between the groups throughout the study. Conclusions The relative hypogonadotrophic hypogonadism of obesity cannot be explained by differences in LH and FSH luteal phase dynamics or differences in endogenous LH pharmacodynamics or exogenous LH pharmacokinetics. |
| Databáze: | OpenAIRE |
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