Clinical Implication and Risk Factors for Malignancy of Atypical Gastric Gland during Forceps Biopsy
| Autor: | Jung Kim, Hyoungju Hong, Sang Gyun Kim, Hyunsoo Chung, Min A Kim, Hyun Chae Jung, Hee Jong Lee, Min Seong Kim, Hyun-Ju Kim, Woo Ho Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adenoma
Male medicine.medical_specialty Biopsy Malignancy Gastroenterology 03 medical and health sciences 0302 clinical medicine Risk Factors Stomach Neoplasms Internal medicine Gastric glands medicine Gastric mucosa Odds Ratio Humans Early Detection of Cancer Aged Retrospective Studies Hepatology medicine.diagnostic_test business.industry Cancer Odds ratio Middle Aged medicine.disease Surgical Instruments Endoscopy medicine.anatomical_structure Gastric Mucosa 030220 oncology & carcinogenesis Gastritis Multivariate Analysis 030211 gastroenterology & hepatology Female business |
| Zdroj: | Gut and liver. 12(5) |
| ISSN: | 2005-1212 |
| Popis: | Background/Aims: Although forceps biopsy is performed for suspicious gastric tumors during endoscopy, it is difficult to determine treatment strategies for atypical gastric glands due to uncertainty of the diagnosis. The aim of this study was to investigate clinical implications and risk factors for predicting malignancy in atypical gastric glands during forceps biopsy. Methods: We retrospectively reviewed medical records of 252 patients with a diagnosis of atypical gastric gland during forceps biopsy. Predictors of malignancy were analyzed using initial endoscopic findings and clinical data. Results: The final diagnosis for 252 consecutive patients was gastric cancer in 189 (75%), adenoma in 26 (10.3%), and gastritis in 37 (14.7%). In the multivariate analysis, lesion sizes of more than 10 mm (odds ratio [OR], 3.021; 95% confidence interval [CI], 1.480 to 6.165; p=0.002), depressed morphology (OR, 3.181; 95% CI, 1.579 to 6.406, p=0.001), and surface nodularity (OR, 3.432; 95% CI, 1.667 to 7.064, p=0.001) were significant risk factors for malignancy. Conclusions: Further evaluation and treatment should be considered for atypical gastric gland during forceps biopsy if there is a large-sized (>10 mm) lesion, depressed morphology, or surface nodularity. (Gut Liver 2018;12:523-529) |
| Databáze: | OpenAIRE |
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