Bio-Nano-Magnetic Materials for Localized Mechanochemical Stimulation of Cell Growth and Death
| Autor: | Cindi L. Dennis, Devrim Kilinc, Gil U. Lee |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Magnetic tweezers Materials science Cancer therapy Mechanotransduction medicine.medical_treatment Nanotechnology Stimulation 02 engineering and technology Mechanotransduction Cellular Article Magnetics 03 medical and health sciences medicine General Materials Science Magnetite Nanoparticles Mechanical Engineering Hyperthermia Induced equipment and supplies 021001 nanoscience & nanotechnology Hyperthermia therapy Magnetic Fields 030104 developmental biology Magnetic hyperthermia Targeted drug delivery Mechanics of Materials Magnetic nanoparticles Cancer cell Biophysics Nanorods 0210 nano-technology human activities |
| Zdroj: | Advanced Materials. 28:5672-5680 |
| ISSN: | 0935-9648 |
| Popis: | Magnetic nanoparticles are promising new tools for therapeutic applications, such as magnetic nanoparticle hyperthermia therapy and targeted drug delivery. Recent in vitro studies have demonstrated that a force application with magnetic tweezers can also affect cell fate, suggesting a therapeutic potential for magnetically modulated mechanical stimulation. The magnetic properties of nanoparticles that induce physical responses and the subtle responses that result from mechanically induced membrane damage and/or intracellular signaling are evaluated. Magnetic particles with various physical, geometric, and magnetic properties and specific functionalization can now be used to apply mechanical force to specific regions of cells, which permit the modulation of cellular behavior through the use of spatially and time controlled magnetic fields. On one hand, mechanochemical stimulation has been used to direct the outgrowth on neuronal growth cones, indicating a therapeutic potential for neural repair. On the other hand, it has been used to kill cancer cells that preferentially express specific receptors. Advances made in the synthesis and characterization of magnetic nanomaterials and a better understanding of cellular mechanotransduction mechanisms may support the translation of mechanochemical stimulation into the clinic as an emerging therapeutic approach. European Commission - European Regional Development Fund Science Foundation Ireland Programme for Research in Third-Level Institutions Marie Curie Intra-European Fellowship |
| Databáze: | OpenAIRE |
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