The myocardium of fetuses with endocardial fibroelastosis contains fewer B and T lymphocytes than normal control myocardium
| Autor: | Lynne E. Nield, Adelle Atkinson, Nisha M. Fernandes, Edgar Jaeggi, Brian W. McCrindle, Steven E. S. Miner, Cedric Manlhiot, Glenn Taylor, Michael Ho |
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| Rok vydání: | 2010 |
| Předmět: |
Cardiomyopathy
Dilated Pathology medicine.medical_specialty T cell T-Lymphocytes Pathogenesis Immune system Fetus medicine Humans Lymphocyte Count B cell B-Lymphocytes business.industry Myocardium Autoantibody Endocardial fibroelastosis Dilated cardiomyopathy Endocardial Fibroelastosis medicine.disease Immunohistochemistry medicine.anatomical_structure Case-Control Studies Pediatrics Perinatology and Child Health Cardiology and Cardiovascular Medicine business CD8 Dilatation Pathologic |
| Zdroj: | Pediatric cardiology. 32(8) |
| ISSN: | 1432-1971 |
| Popis: | The observation that endocardial fibroelastosis (EFE) can result from an immune response to maternal autoantibody deposition in the fetal myocardium raises the possibility that the fetal immune system may contribute to the pathogenesis of idiopathic EFE and dilated cardiomyopathy (DCM). This study sought to characterize myocardial immune cell presence in fetuses and neonates with idiopathic EFE + DCM, in those with EFE + structural heart disease, and in normal control subjects. Paraffin tissue sections from fetuses identified from the pathology database were stained for B cell, T cell, macrophage, and general hematopoietic cell surface markers. Of the 14 fetuses included in the study, 5 had EFE + DCM, 4 had EFE + structural heart disease, and 5 were normal control fetuses. The EFE + DCM group had fewer B cells than the control group (0.15 vs. 0.44 cells/mm(2); p = 0.005). The EFE + heart disease group had both fewer B cells (0.18 vs. 0.44 cells/mm(2); p = 0.08) and T cells (0.29 vs. 0.80 cells/mm(2); p = 0.04) than the control group. The CD4/CD8 ratio was similar in the EFE + DCM and EFE + heart disease groups (1.0 vs. 0.9; p = 0.17) but higher in the EFE + DCM group than in the control group (0.9 vs. 0.3; p = 0.03). The myocardium of fetuses with EFE contains fewer B and T lymphocytes than normal control fetuses. |
| Databáze: | OpenAIRE |
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