The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies
Autor: | Potter, R., Tanderup, K., Kirisits, C., Leeuw, A. de, Kirchheiner, K., Nout, R., Tan, L.T., Haie-Meder, C., Mahantshetty, U., Segedin, B., Hoskin, P., Bruheim, K., Rai, B., Huang, F., Limbergen, E. van, Schmid, M., Nesvacil, N., Sturdza, A., Fokdal, L., Jensen, N.B.K., Georg, D., Assenholt, M., Seppenwoolde, Y., Nomden, C., Fortin, I., Chopra, S., Heide, U. van der, Rumpold, T., Lindegaard, J.C., Jurgenliemk-Schulz, I., Dumas, I., Chargari, C., Swamidas, J., Shrivastava, S.K., Lowe, G., Hudej, R., Hellebust, T.P., Menon, G., Oinam, A.S., Cooper, R., Bownes, P., Banasik, E.V., Sundset, M., Pieters, B., Lutgens, L.C.H.W., Villafranca, E., Hadjiev, J., Bachand, F., Erickson, B., Jacobson, G., Anttila, M., EMBRACE Collaborative Grp |
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Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
STANDARDIZED UPTAKE VALUE MODULATED RADIATION-THERAPY medicine.medical_treatment Brachytherapy R895-920 Translational research LATE RECTAL TOXICITY Article 030218 nuclear medicine & medical imaging Medical physics. Medical radiology. Nuclear medicine 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being RATE INTRACAVITARY BRACHYTHERAPY Cervix cancer QUALITY-OF-LIFE CARBON ION RADIOTHERAPY ADVANCED CERVICAL-CANCER Medicine Radiology Nuclear Medicine and imaging Medical physics External beam radiotherapy Medical prescription RC254-282 ComputingMethodologies_COMPUTERGRAPHICS DOSE-VOLUME PARAMETERS Image-guided radiation therapy Cervical cancer Contouring Manchester Cancer Research Centre business.industry ResearchInstitutes_Networks_Beacons/mcrc Neoplasms. Tumors. Oncology. Including cancer and carcinogens GUIDED ADAPTIVE BRACHYTHERAPY MRI guided radiotherapy medicine.disease 3. Good health Adaptive radiotherapy Oncology EXTERNAL-BEAM RADIOTHERAPY Local control 030220 oncology & carcinogenesis Observational study Morbidity business |
Zdroj: | EMBRACE Collaborative Group 2018, ' The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies ', Clinical and Translational Radiation Oncology, vol. 9, pp. 48-60 . https://doi.org/10.1016/j.ctro.2018.01.001 Clinical and Translational Radiation Oncology, Vol 9, Iss C, Pp 48-60 (2018) EMBRACE Collaborative Group 2018, ' The EMBRACE II study : The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies ', Clinical and translational radiation oncology, vol. 9, pp. 48-60 . https://doi.org/10.1016/j.ctro.2018.01.001 Clinical and Translational Radiation Oncology |
ISSN: | 2405-6308 |
DOI: | 10.1016/j.ctro.2018.01.001 |
Popis: | Graphical abstract Highlights • Image guided adaptive brachytherapy (IGABT) is changing clinical practice. • The EMBRACE studies benchmark IGABT in cervix cancer. • A multi-parametric dose prescription protocol is being validated in EMBRACE II. • EMBRACE II is hypothesised to improve outcome: disease, morbidity, quality of life. The publication of the GEC-ESTRO recommendations one decade ago was a significant step forward for reaching international consensus on adaptive target definition and dose reporting in image guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer. Since then, IGABT has been spreading, particularly in Europe, North America and Asia, and the guidelines have proved their broad acceptance and applicability in clinical practice. However, a unified approach to volume contouring and reporting does not imply a unified administration of treatment, and currently both external beam radiotherapy (EBRT) and IGABT are delivered using a large variety of techniques and prescription/fractionation schedules. With IGABT, local control is excellent in limited and well-responding tumours. The major challenges are currently loco-regional control in advanced tumours, treatment-related morbidity, and distant metastatic disease. Emerging evidence from the RetroEMBRACE and EMBRACE I studies has demonstrated that clinical outcome is related to dose prescription and technique. The next logical step is to demonstrate excellent clinical outcome with the most advanced EBRT and brachytherapy techniques based on an evidence-based prospective dose and volume prescription protocol. The EMBRACE II study is an interventional and observational multicentre study which aims to benchmark a high level of local, nodal and systemic control while limiting morbidity, using state of the art treatment including an advanced target volume selection and contouring protocol for EBRT and brachytherapy, a multi-parametric brachytherapy dose prescription protocol (clinical validation of dose constraints), and use of advanced EBRT (IMRT and IGRT) and brachytherapy (IC/IS) techniques (clinical validation). The study also incorporates translational research including imaging and tissue biomarkers. |
Databáze: | OpenAIRE |
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