Cardiovascular risk factors, anxiety symptoms and inflammation markers: Evidence of association from a cross-sectional study
| Autor: | Gian Maria Galeazzi, Giulia Rioli, Giacomo Galli, Nina Giambalvo, Silvia Ferrari, Alessandro Minarini, Luca Roncucci, Daniela Perrone, Cecilia Artoni, Giulia Spiga, Mattia Marchi, Giulia Montardi, Chiara Visentini, S. Tassi, Martina Galletti, Giorgio Mattei, Gabriella Pollutri, Silvia Alboni, Serena Saraceni, Stefano Mancini |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test Cross-sectional study business.industry C-reactive protein Overweight Psychiatry and Mental health Internal medicine Epidemiology medicine biology.protein Anxiety Medical history medicine.symptom business Psychiatry Lipid profile Depression (differential diagnoses) |
| Zdroj: | European Psychiatry. 41:s503-s503 |
| ISSN: | 1778-3585 0924-9338 |
| Popis: | IntroductionAnxiety disorders and Cardiovascular (CV) diseases, among the most common disorders in Western World, are often comorbid. A chronic systemic inflammatory state might be a shared underlining pathophysiological mechanism.AimsTo investigate the association between anxiety symptoms, CV risks factors and inflammatory markers in an outpatient sample.MethodsCross-sectional study. Inclusion criteria: outpatients aged ≥40 years, attending colonoscopy after positive faecal occult blood test, negative medical history for cancer. Collected data: blood pressure, glycaemia, lipid profile, waist circumference, BMI, PCR (C Reactive Protein), LPS (bacterial Lipopolysaccharide). Psychometric tests: HADS, TCI, IMSA, SF36. Statistical analysis performed with STATA13.ResultsFifty four patients enrolled (27 males, 27 females). Sixteen patients (30.19%) were positive for anxiety symptoms. Thirty-three patients (61.11%) had hypertension, 14 (25.93%) hyperglycaemia and 64.81% were overweight, with frank obesity (BMI≥ 30) in 11 subjects (20.37%). Anxiety symptoms were associated with low hematic HDL values (OR = 0.01; P = 0.01) and high concentration of triglycerides (OR = 0.023; P = 0.02) at the multiple regression model. At the univariate logistic analysis, anxiety was associated with LPS (OR = 1.06; P = 0.04).ConclusionsFurther evidence over the epidemiological link between common mental disorders and CV diseases was collected, with possible hints on pathophysiology and causative mechanisms related to inflammation. The importance of screening for anxiety and depression in medical populations is confirmed. Suggestions on future availability of screening tools based on inflammatory-related indicators should be the focus of future research.Disclosure of interestThe authors have not supplied their declaration of competing interest. |
| Databáze: | OpenAIRE |
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