Paradoxical stimulation of matrix metalloproteinase-9 expression in HT1080 cells by a broad-spectrum hydroxamate-based matrix metalloproteinase inhibitor
| Autor: | Carine Munaut, Jean-Michel Foidart, Frank Grams, H. W. Krell, Alain Colige, Francis Frankenne, Erik Maquoi, Agnès Noël, Charles Lambert |
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| Rok vydání: | 1999 |
| Předmět: |
Transcription
Genetic Matrix metalloproteinase inhibitor Fibrosarcoma Phenylalanine Matrix metallopeptidase 12 Matrix metalloproteinase Hydroxamic Acids General Biochemistry Genetics and Molecular Biology Gene Expression Regulation Enzymologic Metastasis Type IV collagen History and Philosophy of Science In vivo Genes Reporter medicine Tumor Cells Cultured Humans Neoplasm Invasiveness Protease Inhibitors Collagenases Promoter Regions Genetic Chemistry General Neuroscience Metalloendopeptidases medicine.disease In vitro Matrix Metalloproteinase 9 Cancer research HT1080 Collagen |
| Zdroj: | Annals of the New York Academy of Sciences. 878 |
| ISSN: | 0077-8923 |
| Popis: | Due to their unusual ability to cleave and degrade a variety of ECM components, including triple-helical type IV collagen, two members of the family of matrix metalloproteinases (MMPs), MMP-2 and MMP-9, are thought to play critical roles during tumor invasion and metastasis. The proteolytic activity of mature MMPs is modulated by a group of specific inhibitors, the tissue inhibitors of metalloproteinases (TIMPs). Excessive ECM degradation observed during tumor invasion and metastasis frequently correlates with an excess of active MMPs. Therefore, adding exogenous inhibitors was contemplated for anticancer therapy. Indeed, synthetic MMP inhibitors have been demonstrated to reduce tumor invasion and metastasis in several in vitro and in vivo models. |
| Databáze: | OpenAIRE |
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