Novel benzimidazole-based MCH R1 antagonists

Autor:	Jason D. Speake, Ronda O. Morgan, Diane M. Ignar, Peckham Gregory, Kamal A. Al-Barazanji, Aaron S. Goetz, Will R. Swain, Christy S. Britt, Joel P. Cooper, Kevin K Barvian, Mary K. Grizzle, Donald L. Hertzog, Michael J. Bishop, Andrew J. Carpenter
Rok vydání:	2006
Předmět:	medicine.medical_specialty Benzimidazole Clinical Biochemistry Pharmaceutical Science Biological Availability Pharmacology Biochemistry chemistry.chemical_compound Mice Structure-Activity Relationship Animal model Internal medicine Drug Discovery Weight Loss medicine Animals Obesity Receptors Somatostatin Molecular Biology Dose-Response Relationship Drug Organic Chemistry Antagonist Nutritional status respiratory system Endocrinology chemistry Models Animal Body Composition Molecular Medicine Benzimidazoles hormones hormone substitutes and hormone antagonists
Zdroj:	Bioorganicmedicinal chemistry letters. 16(19)
ISSN:	0960-894X
Popis:	The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure–activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5772f72574c5968fd282d49409571c2 https://pubmed.ncbi.nlm.nih.gov/16904318 Zobrazit plný text záznamu Full Text from ScienceDirect