Angiotensin II Induces Modulation of Calcium Channel Currents in Osteoblasts

Autor: Hiroshi Kobayashi, Takayuki Endoh, Mai Ohkubo, Kenji Sueishi, Masakazu Tazaki
Rok vydání: 2013
Předmět:
Zdroj: The Bulletin of Tokyo Dental College. 54:275-278
ISSN: 0040-8891
DOI: 10.2209/tdcpublication.54.275
Popis: Angiotensin II (Ang II) plays a major role in the maintenance of extracellular fluid volume and blood pressure. In addition to its well-established role in circulatory homeostasis, it has been implicated in the process of bone formation. Osteoblasts play a major role in bone formation, employing intracellular Ca(2+) as a second messenger to modulate hormonal responses and as a cofactor for mineralization. Voltage-dependent Ca(2+) channels (VDCCs) mediate the influx of Ca(2+) in response to membrane depolarization. The purpose of this study was to investigate the effects of Ang II on VDCC currents in osteoblasts using a patch-clamp recording method. To our knowledge, the data presented here demonstrate for the first time that Ang II facilitates VDCCs in osteoblasts.
Databáze: OpenAIRE