Angiotensin II Induces Modulation of Calcium Channel Currents in Osteoblasts
Autor: | Hiroshi Kobayashi, Takayuki Endoh, Mai Ohkubo, Kenji Sueishi, Masakazu Tazaki |
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Rok vydání: | 2013 |
Předmět: |
Osteoblasts
Patch-Clamp Techniques Chemistry Angiotensin II Calcium channel Cell Culture Techniques Depolarization Osteoblast 3T3 Cells General Medicine Cell biology Mice Calcification Physiologic medicine.anatomical_structure Osteogenesis Extracellular fluid Second messenger system medicine Animals Calcium Channels Calcium Signaling Patch clamp Homeostasis |
Zdroj: | The Bulletin of Tokyo Dental College. 54:275-278 |
ISSN: | 0040-8891 |
DOI: | 10.2209/tdcpublication.54.275 |
Popis: | Angiotensin II (Ang II) plays a major role in the maintenance of extracellular fluid volume and blood pressure. In addition to its well-established role in circulatory homeostasis, it has been implicated in the process of bone formation. Osteoblasts play a major role in bone formation, employing intracellular Ca(2+) as a second messenger to modulate hormonal responses and as a cofactor for mineralization. Voltage-dependent Ca(2+) channels (VDCCs) mediate the influx of Ca(2+) in response to membrane depolarization. The purpose of this study was to investigate the effects of Ang II on VDCC currents in osteoblasts using a patch-clamp recording method. To our knowledge, the data presented here demonstrate for the first time that Ang II facilitates VDCCs in osteoblasts. |
Databáze: | OpenAIRE |
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