The correlation between neurosteroids and neurotransmitters with liver yang rising and liver qi stagnation types of premenstrual syndrome

Autor:	Tian Xia, Yue Xiang Ma, Hui Yun Zhang, Ya Zhen Shang, Hui Gao, Mingqi Qiao
Rok vydání:	2014
Předmět:	Adult medicine.medical_specialty Serotonin Neuroactive steroid Qi Endocrinology Diabetes and Metabolism Dopamine Pregnanolone Luteal phase Premenstrual Syndrome chemistry.chemical_compound Young Adult Endocrinology Internal medicine Follicular phase medicine Humans Yin-Yang Testosterone Medicine Chinese Traditional Progesterone gamma-Aminobutyric Acid Neurotransmitter Agents business.industry Allopregnanolone Obstetrics and Gynecology Radioimmunoassay Dehydroepiandrosterone Middle Aged chemistry Liver Pregnenolone Female business medicine.drug Hormone
Zdroj:	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 30(12)
ISSN:	1473-0766
Popis:	To investigate neural-reproductive hormonal basis of liver yang rising (LYR), liver qi stagnation (LQS) premenstrual syndrome (PMS), and to develop standardized diagnostic criteria for PMS.HPLC, HPLC-MC, ELISA and radioimmunoassay were used to compare levels of serum hormones, plasma neurotransmitters and neurosteroids between LYR PMS patients, LQS PMS patients and healthy controls (30 subjects in each group).Of the measures, all three groups exhibited no significant differences during the follicular phase. In contrast, during the luteal phase, LYR PMS testosterone levels tended to be higher than controls, while dopamine and 5-HT of the LYR PMS group were significantly higher. Conversely, γ-aminobutyric acid in the LYR PMS group was significantly lower than controls (p 0.05). On the other hand, epinephrine and norepinephrine levels in both PMS groups were significantly higher than controls (p 0.05), while pregnenolone and allopregnanolone of LYR and LQS groups were significantly lower than controls, with dehydroepiandrosterone (DHEA) being significantly higher than controls (p 0.05). The ratios of DHEA/allopregnanolone and DHEA/pregnenolone of both PMS groups were significantly higher than the control group, with the LYR PMS group ratios being significantly higher than in the LQS PMS group (p 0.05).The decrease in pregnenolone and allopregnenolone, increase in DHEA, DHEA/allopregnanolone and DHEA/pregnenolone during the luteal phase may be one of the biological bases for anger in LYR PMS patients and depression in LQS PMS patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5743e983d57ffd7aeec6d41c0eaa05e https://pubmed.ncbi.nlm.nih.gov/25211539 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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